grant
Multiscale Computational Microscopy of HIV-1
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 7 Jul 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoVAIDSAIDS VirusAIDS preventionAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency SyndromeAcquired Immunodeficiency Syndrome VirusAddressAntigensBackBiologyCOVID-19 virusCOVID19 virusCell BodyCell CoatCellsChimera ProteinChimeric ProteinsCoV-2CoV2CollaborationsCrowdingCryo-electron MicroscopyCryo-electron tomographyCryoelectron MicroscopyDataData SetDiseaseDisorderDorsumElectron CryomicroscopyElementsEnvelope ProteinExhibitsFusion ProteinFuture GenerationsGlycansGlycocalyxGoalsGrippeHIVHIV PreventionHIV vaccineHIV-1HIV-IHIV/AIDS VaccinesHIV/AIDS preventionHIV1Heparan SulfateHeparitin SulfateHumanHuman Immunodeficiency Virus Type 1Human Immunodeficiency VirusesHuman immunodeficiency virus 1Immune systemInfectionInfection preventionInfluenzaKnowledgeLAV-HTLV-IIILinkLymphadenopathy-Associated VirusMacromolecular StructureMethodsMicroscopeMicroscopyModelingModern ManMolecular Dynamics SimulationMolecular StructureMucinsMucus GlycoproteinMutateNational Institutes of HealthNon-Polyadenylated RNAOutcomePatternPersonsPhysiologicPhysiologicalPlayPolysaccharidesPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPrevent infectionProtein DynamicsProtein ModificationRNARNA Gene ProductsReceptor ProteinResolutionRetroviridaeRetrovirusesRibonucleic AcidSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2ScientistSeriesSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome related corona virus 2SiteStructural BiologistStructureSurfaceTechniquesTherapeuticTimeTranslatingUnited States National Institutes of HealthUtahVaccinesViralViral Fusion ProteinsViral Gene ProductsViral Gene ProteinsViral ProteinsVirionVirusVirus ParticleVirus-HIVVirus-RetrovirusWuhan coronavirusadvanced simulationcoronavirus disease 2019 viruscoronavirus disease-19 viruscryo-EMcryo-EM tomographycryoEMcryoEM tomographycryoelectron tomographycryogenic electron microscopydensitydesigndesigningelectron cryo-tomographyenv Antigensenv Gene Productsenv Polyproteinsenv Proteinexperimentexperimental researchexperimental studyexperimentsflexibilityflexiblehCoV19human immunodeficiency virus vaccineimmunogenimmunogenicimprovedin vivoinfection rateinsightinterestmodel buildingmolecular dynamicsnCoV2novelrate of infectionreceptorresolutionssimulationsmall moleculestructural biologyvirus protein
Description preview
ABSTRACT
The human immunodeficiency virus 1 (HIV-1) is the RNA retrovirus that causes acquired
immunodeficiency syndrome (AIDS), a disease that has killed over 40 million people worldwide
and infected more than twice that. Continued high infection rates has made understanding of
HIV biology and vaccines a high priority. A key molecule involved in…
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