grant
Multimodal imaging of prenatal alcohol exposure: Mechanisms underlying spatial navigation memory deficits in children and adolescents
Organization LOVELACE BIOMEDICAL RESEARCH INSTITUTELocation ALBUQUERQUE, UNITED STATESPosted 1 Sept 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY20250-11 years old14 year old14 years of age21+ years oldAccelerationAddressAdolescentAdolescent YouthAdultAdult HumanAgeAmmon HornBrainBrain Nervous SystemCharacteristicsChildChild YouthChildren (0-21)Cognitive deficitsCornu AmmonisDevelopmentDiagnosisDiagnosticEarly InterventionEarly identificationEncephalonEquilibriumEventFASDFetal Alcohol ExposureFetal Alcohol Spectrum DisorderFetal ETOH ExposureFetal Ethanol ExposureFunctional MRIFunctional Magnetic Resonance ImagingFutureGoalsHippocampusHumanHydrogen OxideIQ DeficitImmediate MemoryImpairmentIn Utero Alcohol ExposureIn Utero ETOH ExposureIn Utero Ethanol ExposureIndividualInterventionIntervention StudiesInvestigatorsKnowledgeMaintenanceMemoryMemory DeficitMemory impairmentModern ManMultimodal ImagingNIAAANational Institute on Alcohol Abuse and AlcoholismNeurocognitive DeficitNeurodevelopmental DisorderNeurological Development DisorderParticipantPlayPrefrontal CortexPrenatal Alcohol ExposurePrenatal ETOH ExposurePrenatal Ethanol ExposurePrevalenceProblem SolvingProblem behaviorQOLQuality of lifeResearchResearch PersonnelResearchersResolutionRodentRodent ModelRodentiaRodents MammalsRoleScanningSchool-Age PopulationShort-Term MemorySpecificityStrategic PlanningSynapsesSynapticTask PerformancesTimeUnited StatesWaterWomanWorkadulthoodage 14 yearsage associatedage correlatedage dependentage linkedage relatedage specificagesalcohol consequencesalcohol exposedalcohol exposurealcohol related consequencesalcohol-exposed pregnancybalancebalance functionbehavioral problemcognitive defectsdevelop therapydevelopmentalearly alcohol useearly in pregnancyearly onset alcohol useearly pregnanciesearly pregnancyearly stage of pregnancyethanol exposedethanol exposureexposed to alcoholexposed to alcohol prenatallyexposed to ethanolexposure to alcoholexposure to ethanolfMRIfetal diagnosisfourteen year oldfourteen years of agegestation ETOH exposuregestation alcohol exposuregestation ethanol exposuregestational ethanol exposurehippocampalimprovedimproved outcomeindexinginnovateinnovationinnovativeintelligence quotient deficitintervention developmentintervention researchinterventional researchinterventional studyinterventions researchjuvenilejuvenile humankidsmemory consolidationmemory dysfunctionmemory encodingmulti-modal imagingmulti-modal neuro-imagingmulti-modalitymulti-modality imagingmultimodal data fusionmultimodal fusionmultimodal neuroimagingmultimodalitymultimodality imagingneuralneural circuitneural circuitryneural imagingneural mechanismneuro-imagingneurocircuitryneurocognitive declineneurocognitive impairmentneurodevelopmental diseaseneuroimagingneurological imagingneuromechanismneurophysiologicalneurophysiologynew approachesnovelnovel approachesnovel strategiesnovel strategypregnancy ETOH exposurepregnancy alcohol exposurepregnancy ethanol exposureprenatalprenatally alcohol exposedprenatally exposed to alcoholrecruitresolutionsschool ageskillssocial rolespatial memoryspatial navigationsynapsesynaptic circuitsynaptic circuitrytemporal measurementtemporal resolutiontherapy developmenttime measurementtooltreatment developmentunbornvirtualway findingwayfindingworking memoryyoungster
Description preview
Project Summary/Abstract
Exposure to alcohol during prenatal brain development, perturbs hippocampal development and
results in lifelong cognitive deficits in spatial memory. While rodent models have characterized
cellular and synaptic changes produced by prenatal alcohol exposure (PAE), the
neurophysiological mechanisms in humans remains poorly…
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