grant
Multimodal brain imaging of the neural effects of methylphenidate in patients with ADHD
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 1 Dec 2023Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY20250-11 years old21+ years old4-Aminobutanoic Acid4-Aminobutyric Acid4-amino-butanoic acidAD/HDADHDAcuteAdolescentAdolescent YouthAdultAdult HumanAgeAminalonAminaloneAnteriorAttentionAttention deficit hyperactivity disorderBiological MarkersBlood PlasmaBrainBrain ChemistryBrain Nervous SystemBrain imagingBrain regionCNS DiseasesCNS Nervous SystemCNS disorderCentral Nervous SystemCentral Nervous System DiseasesCentral Nervous System DisordersChemicalsChildChild YouthChildhoodChildren (0-21)CognitionCognitiveCognitive ManifestationsCognitive SymptomsCognitive deficitsCommunitiesConcertaDataDaytranaDevelopmentDiseaseDisorderDopamineDoseDouble-Blind MethodDouble-Blind StudyDouble-BlindedDouble-Masked MethodDouble-Masked StudyDrug TherapyDrugsDysfunctionEncephalonFunctional MRIFunctional Magnetic Resonance ImagingFunctional disorderFutureGABAGlutamatesGoalsHigh PrevalenceHydroxytyramineImageImaging DeviceImaging InstrumentImaging ProceduresImaging TechnicsImaging TechniquesImaging ToolImmediate MemoryL-GlutamateLevarterenolLevonorepinephrineLightLinkMR SpectroscopyMRI biomarkerMRI markerMagnetic Resonance SpectroscopyMeasurableMeasuresMedicationMetadateMethylphenidateN-acetyl-1-Asp-GluN-acetyl-aspartyl-glutamateN-acetylaspartylglutamateNational Institutes of HealthNeuraxisNeurobehavioral ManifestationsNeurobehavioral Signs and SymptomsNoradrenalineNorepinephrineOralOutcomePathway interactionsPatientsPatternPharmaceutical PreparationsPharmacodynamicsPharmacological TreatmentPharmacotherapyPhotoradiationPhysiopathologyPlacebosPlasmaPlasma SerumPopulationPredominantly Hyperactive-Impulsive Type Attention-Deficit DisorderPredominantly Hyperactive-Impulsive Type Hyperactivity DisorderPrefrontal CortexPublic HealthReproducibilityResearchReticuloendothelial System, Serum, PlasmaRitalinSham TreatmentShort-Term MemoryStimulantSymptomsTestingUnited States National Institutes of Healthadulthoodagesbio-markersbiologic markerbiomarkerbrain visualizationchild patientscingulate cortexcognitive defectscognitive performancecognitive taskdevelopmentaldrug developmentdrug interventiondrug treatmentdrug/agentfMRIgamma-Aminobutyric Acidglutamatergicimagingimprovedinsightinterestjuvenilejuvenile humankidsmagnetic resonance imaging biomarkermagnetic resonance imaging markermulti-modalitymultimodalityneuralneural correlateneural imagingneural networkneural patterningneuro-imagingneurobehavioral symptomneuroimagingneuroimaging biomarkerneuroimaging markerneurological imagingnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathophysiologypathwaypediatricpediatric patientspharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsresponseresponse to therapyresponse to treatmentsham therapyside effecttherapeutic responsetherapy responsetreatment responsetreatment responsivenesstreatment trialworking memoryyoungsterγ-Aminobutyric Acid
Description preview
There is continued interest to develop novel pharmacological treatments for attention deficit
hyperactivity disorder (ADHD), in part because of its high prevalence in the community, and lack
of optimal response to current medications, including intolerable side effects. Central nervous
system (CNS) pharmacodynamic (PD) measures have not been well…
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