grant
Multicellular Mechanisms Driving Axon Regeneration
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 17 May 2021Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2025AffectAfferent NeuronsAutomobile DrivingAxonBiologic ModelsBiological ModelsCNS InjuryCNS Nervous SystemCell BodyCellsCentral Nervous SystemChromatinCranial Nerve IICranial Nerve II InjuriesEnvironmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEsthesiaFailureFutureGene TranscriptionGenesGenetic TranscriptionGliaGlial CellsGoalsHumanIndividualKolliker's reticulumLeadLifelong disabilityMiceMice MammalsModel SystemModern ManMolecular ConfigurationMolecular ConformationMolecular FingerprintingMolecular ProfilingMolecular StereochemistryMurineMusNatural regenerationNerve CellsNerve UnitNervous System InjuriesNervous System TraumaNervous System damageNeural CellNeuraxisNeurobiologyNeurocyteNeurogliaNeuroglial CellsNeurological DamageNeurological InjuryNeurological traumaNeuronsNon-neuronal cellNonneuronal cellOptic NerveOptic Nerve InjuriesOptic Nerve TraumaPathway interactionsPb elementPeripheralPermanent disabilityPhysiologyProcessRNA ExpressionRecoveryRegenerationRegenerative capacityRegulationResearchSecond Cranial NerveSecond Cranial Nerve InjuriesSecond Cranial Nerve TraumaSensationSensory GangliaSensory NeuronsSightSiteSpinal Cord TraumaSpinal TraumaSpinal cord injuredSpinal cord injuryTranscriptionTraumatic MyelopathyTraumatic Optic NeuropathyVisionaxon damageaxon growthaxon injuryaxon regenerationaxonal damageaxonal growthaxonal injuryaxonal regenerationcell typecentral nervous system injuryconformationconformationalconformational stateconformationallyconformationsdrivingepigeneticallyepigenomicsheavy metal Pbheavy metal leadimprovedinjuredinjured CNSinnovateinnovationinnovativemolecular profilemolecular signaturemouse modelmurine modelnerve cementnerve damagenerve reconstructionnerve repairneural cell bodyneurobiologicalneuronalneuronal cell bodyneurotraumanew approachesnovelnovel approachesnovel strategiesnovel strategypathwayprogramsregenerateregeneration abilityregeneration capacityregenerativerepairrepairedsomasuccesstoolvisual function
Description preview
ABSTRACT
Permanent disabilities following central nervous system (CNS) injuries result from the failure of injured
axons to re-build functional connections. There are currently no therapies to restore mobility and sensation
following spinal cord injury or vision after optic nerve damage. The poor intrinsic regenerative capacity of
mature CNS…
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