grant
Multi-Omics Correlates of Broadly Neutralizing Antibody Efficacy
Organization BETH ISRAEL DEACONESS MEDICAL CENTERLocation BOSTON, UNITED STATESPosted 11 Jul 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2025Antibody TherapyBody TissuesCITE sequencingCITE-seqCITEseqCell BodyCell Mediated ImmunologyCell surfaceCell-Mediated ImmunityCellsCellular ImmunityCellular Indexing of Transcriptomes and Epitopes by SequencingChromatinClinicalClinical TrialsComputer AnalysisDataDoseDrug KineticsEffectivenessGene TranscriptionGenetic TranscriptionGenomicsHIV-1HIV-IHIV1HumanHuman Immunodeficiency Virus Type 1Human immunodeficiency virus 1Immune responseImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsIn SituIndividualInfusionInfusion proceduresIntervention StudiesLymph Node Reticuloendothelial SystemLymph node properLymphatic TissueLymphatic nodesLymphoid TissueMacacaMacaqueMeasuresModern ManMolecular FingerprintingMolecular ProfilingMucosaMucosal TissueMucous MembraneMultiomic DataParticipantPharmacokineticsPhenotypePropertyProteinsProteomicsRNA ExpressionReportingResearch SpecimenResistanceResolutionSHIVSpecimenTestingTherapeuticTissue SampleTissuesTranscriptTranscriptionVAC-TXVaccine TherapyVaccinesViralViral ActivityViral FunctionViral PhysiologyViral reservoirVirusVirus ReplicationVirus reservoiranti-viral efficacyantibody based therapiesantibody treatmentantibody-based therapeuticsantibody-based treatmentcellular indexing of transcriptomes and epitopes by single cell sequencingchallenge in rhesus macaquescomputational analysescomputational analysiscomputer analysesgastrointestinalhost responseimmune system responseimmunoresponseinfected rhesus macaquesinfected rhesus monkeyinfection in rhesus macaquesinfection of rhesus macaquesinfusionsinsightintervention researchinterventional researchinterventional studyinterventions researchlymph glandlymph nodeslymphnodesmolecular profilemolecular signaturemultiomicsmultiple omic datamultiple omicsneutralizing antibodynext generationnon-human primatenonhuman primatepanomicsprotein biomarkersprotein markersresistantresolutionsrhesus challengerhesus macaque challengerhesus monkey infectionscATAC sequencingscATAC-seqscRNA sequencingscRNA-seqsimian HIVsimian human immunodeficiency virussingle cell ATAC-seqsingle cell ATAC-sequencingsingle cell Assay for Transposase Accessible Chromatin sequencingsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell sequencing assay for transposase accessible chromatinsingle cell transcriptomic profilingsingle-cell Assay for Transposase-Accessible Chromatin with sequencingsingle-cell RNA sequencingsingle-cell assay for transposase-accessible chromatin using sequencingsingle-cell assay for transposase-accessible chromatin-seqspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicstherapeutic vaccinationtranscriptomicsviral DNAviral RNAviral detectionviral multiplicationviral reboundviral replicationvirus DNAvirus RNAvirus detectionvirus multiplicationvirus rebound
Description preview
SUMMARY
Accumulating data suggests that administration of broadly neutralizing antibodies (bNAbs) in ART-suppressed,
SHIV-infected nonhuman primates (NHPs) and HIV-1-infected humans can delay viral rebound following ART
discontinuation. However, the mechanism underlying the efficacy of bNAbs remains to be determined. Multiple
mechanisms may…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click