grant
Multi-omics approaches to lower the barriers to sustainable production of plant natural products with relevance to human health
Organization UNIVERSITY OF GEORGIALocation ATHENS, UNITED STATESPosted 1 Mar 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY20253-D3-Dimensional3D5'-Nor-AnhydrovinblastineATAC sequencingATAC-seqATACseqAccelerationAddressAnabolismAnalgesic AgentsAnalgesic DrugsAnalgesic PreparationAnalgesicsAnodynesAnti-Cancer AgentsAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAnti-malarialsAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsAntinociceptive AgentsAntinociceptive DrugsAnzataxAsotaxAssayAssay for Transposase-Accessible Chromatin using sequencingBasal Transcription FactorBasal transcription factor genesBioassayBiological AssayBlossomsBody TissuesBone callusBony CallusBotanical natural productsBotanicalsBristaxolCallusCancer DrugCandidate Disease GeneCandidate GeneCatharanthus roseusCell BodyCell Communication and SignalingCell Culture SystemCell Culture TechniquesCell NucleusCell SignalingCellsCellular biologyChromatinChromosomesChromosomes DChromosomes, Human, 13-15ClinicalComplexComplex MixturesCultured CellsDataData SetDevelopmentDihydroxydeoxynorvinkaleukoblastineEconomicsEngineeringFinding natural productsFlowersGene ClusterGene CombinationsGene ExpressionGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGenesGenomeGenomic approachGenomicsGroup D ChromosomesHandHealthHeterogeneityHi-CHumanImprove AccessIndole AlkaloidsIntermediary MetabolismIntracellular Communication and SignalingKnowledgeMadagascar PeriwinkleMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMedicalMedicineMetabolic PathwayMetabolic ProcessesMetabolismMethodologyModern ManMolecular ConfigurationMolecular ConformationMolecular StereochemistryMonoterpenesMonoterpenoidsNatural ProductsNatural product discoveryNeoplastic Disease Chemotherapeutic AgentsNicotianaNucleusOrganPaclitaxelPaclitaxel (Taxol)PainPainfulPathway interactionsPharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePlant BloomsPlant GenesPlant GenomePlant LeavesPlant natural productPlant-based Natural ProductPlant-derived natural productsPlantsPopulationPraxelProductionRegulationRegulatory ElementRenaissanceResolutionSignal TransductionSignal Transduction SystemsSignalingSingle-Nucleus SequencingSuspension CultureSystemTaxolTaxol ATaxol KonzentratTechnologyTissuesTobaccoTranscription Factor Proto-OncogeneTranscription factor genesTumor-Specific Treatment AgentsVinblastineVinca roseaVincaleucoblastineVincaleukoblastineVinorelbineYeastsanti-cancer druganti-malarial agentsanti-malarial drugsanticancer activityassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbiological signal transductionbiosynthesiscandidate identificationcell biologycell culturecell culturescell typeclinical applicabilityclinical applicationclinical relevanceclinically relevantconformationconformationalconformational stateconformationallyconformationsdevelopmentaldiscover genesdrug developmenteconomicempowermentexperimentexperimental researchexperimental studyexperimentsfitnessgene discoverygene productgenome scalegenome-widegenomewidegenomic effortgenomic strategyhandshuman diseaseimprovedinnovateinnovationinnovativeinterestleafmRNA sequencingmRNA-seqmRNAseqmanufacturing facilitymanufacturing plantsmetabolic engineeringmetabolism measurementmetabolomicsmetabonomicsmicrobialminiaturizeminiaturizedmultiomicsmultiple omicsnaturally occurring productnext generationpain killerpain medicationpain relieverpainkillerpanomicspathwaypharmaceuticalpharmacologicproduction plantsreconstitutereconstitutionresolutionssNuc-Seqsingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqstemsuccesssynthetic biologythree dimensionaltooltranscription factortranscriptomics
Description preview
PROJECT SUMMARY
Plants synthesize complex molecules for defense and signaling using specialized metabolic pathways.
These plant natural products enhance their own evolutionary fitness and many of these molecules have been
used with great success as pharmaceuticals to treat a wide range of human diseases as exemplified by Paclitaxel
and…
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