grant
MTSS1 in myocardial disease
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 15 Jul 2019Deadline 31 May 2029
NIHUS FederalResearch GrantFY202521+ years oldAdhesionsAdrenergic AgentsAdrenergic DrugsAdrenergicsAdultAdult HumanAffectAllelesAllelomorphsAnimal ModelAnimal Models and Related StudiesAwardBiologyCardiacCardiac Muscle CellsCardiac MyocytesCardiocyteCardiomyopathiesCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCell LocomotionCell MigrationCell MovementCellular MatrixCellular MigrationCellular MotilityClinicalCongestive CardiomyopathyCytoskeletal SystemCytoskeletonDNADataDeoxyribonucleic AcidDependenceDifferences between sexesDiffers between sexesDilated CardiomyopathyDiseaseDisorderEndocrine Gland SecretionExclusionFIRST AwardFailureFemaleFirst Independent Research Support and Transition AwardsFour Core GenotypesGWA studyGWASGene ExpressionGene variantGene x Environment InteractionGenesGeneticGenetic MedicineGenomicsGonadal Steroid HormonesGonosomesGxE interactionHeartHeart Muscle CellsHeart VascularHeart failureHeart myocyteHeritabilityHormonesHumanIn VitroKnock-outKnockoutLaboratoriesLeadLeftMagnetic ResonanceMapsMeasuresMediatingMeta-AnalysisMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMiceMice MammalsModelingModern ManMurineMusMyocardialMyocardial DiseasesMyocardial DisorderMyocardiopathiesNeoplasm MetastasisParticipantPb elementPersonalized medical approachPopulationProteinsProxyPublic HealthQTLQuantitative Trait LociRegulationResearchResearch ResourcesResourcesRiskRisk FactorsSecondary NeoplasmSecondary TumorSex ChromosomesSex DifferencesSex HormonesSex Steroid HormonesSexual differencesStructureTestingTherapeutic HormoneTransgenic ModelTranslatingUpstream EnhancerVariantVariationVentricularWomanadulthoodallelic variantbenefit sharingbiobankbiorepositorycancer metastasiscardiac MRIcardiac failurecardiac functioncardiac magnetic resonance imagingcardiomyocytecell motilitycirculatory systemcohortenvironment effect on geneexperimentexperimental researchexperimental studyexperimentsfunction of the heartgene environment interactiongene interactiongenetic variantgenome scalegenome wide associationgenome wide association scangenome wide association studygenome-widegenomewidegenomewide association scangenomewide association studygenomic datagenomic datasetgenomic variantgonadal steroidsheart functionheavy metal Pbheavy metal leadhuman modelimprovedin vivoindividualized approachintracellular skeletonmenmodel of animalmodel of humanmouse modelmurine modelmyocardium diseasemyocardium disordernovelpersonalized approachprecision approachprecision medicineprecision-based medicinesexsex based differencessex dimorphismsex steroidsex-dependent differencessex-related differencessex-specific differencessexual dimorphismsexually dimorphictailored approachtraittransgenic traittumor cell metastasiswhole genome association analysiswhole genome association study♀
Description preview
PROJECT SUMMARY
Myocardial disorders lead to heart failure (HF) and impose an enormous public health burden. Changes in
cardiac structure and function that accompany myocardial disease and HF are heritable traits. MTSS1
(metastasis suppressor 1) is an I-BAR protein that regulates cytoskeleton dynamics, cell motility, and adhesion.
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