grant
MTAP-MAT2A synthetic-lethality induced by transition state analogs
Organization ALBERT EINSTEIN COLLEGE OF MEDICINELocation BRONX, UNITED STATESPosted 1 May 2026Deadline 30 Apr 2031
NIHUS FederalResearch GrantFY2026ATP-Methionine S-AdenosyltransferaseAdemetionineAdoMetApcMin/+ApcMin/+ miceApoptosisApoptosis PathwayAssayBindingBioassayBioavailabilityBiological AssayBiological AvailabilityBody TissuesBowel CancerCancer CenterCancer PatientCancer TreatmentCancersCatchment AreaCell BodyCell LineCellLineCellsCellular ExpansionCellular GrowthClinical TrialsCollaborationsColonColon NeoplasmsColon TumorColonic MassColonic NeoplasmsColonic TumorColorectal CancerColorectal NeoplasmsColorectal TumorsCombined Modality TherapyComprehensive Cancer CenterDNA mutationDataDiffusionDoseDrug PrecursorsDrug TargetingDrug TherapyDrugsEnzyme GeneEnzymesExclusionFutureGeneralized GrowthGenerationsGeneticGenetic ChangeGenetic defectGenetic mutationGenotypeGlucan PhosphorylaseGrowthHeterograftHeterologous TransplantationHumanIn VitroInduction of ApoptosisInhibition of Cancer Cell GrowthIntermediary MetabolismIntestinal CancerIntestinal NeoplasiaIntestinal NeoplasmsIntestinal TumorIntestines NeoplasmsKISS1KISS1 Metastasis SuppressorKISS1 geneKiSS-1Large Bowel TumorLarge Intestine NeoplasmLarge Intestine TumorLeadLinkMGC39258Malignant CellMalignant Intestinal NeoplasmMalignant Intestinal TumorMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMediatingMedicationMetabolic ProcessesMetabolismMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMetastinMethodsMethylationMiceMice MammalsModelingModern ManMolecular InteractionMucosaMucosal TissueMucous MembraneMultimodal TherapyMultimodal TreatmentMurineMusMutationNeoplasm MetastasisNormal TissueNormal tissue morphologyOralOrganoidsPatientsPb elementPharmaceutical PreparationsPharmacodynamicsPharmacological TreatmentPharmacotherapyPhenotypePhosphorylasesPhysiologic AvailabilityPopulationPredispositionPresbyterian ChurchPresbyteriansPro-DrugsProdrugsProgrammed Cell DeathProtocolProtocols documentationRecyclingRegulatory ProteinReportingRodentRodentiaRodents MammalsRoleS-AdenosylhomocysteineS-AdenosylmethionineS-Adenosylmethionine SynthetaseS-adenosyl methionineS-adenosyl-methionineSAMeSecondary NeoplasmSecondary TumorSourceSpecificityStrains Cell LinesStructureSusceptibilitySystemTestingTissue GrowthTissuesToxic effectToxicitiesToxicologyTumor CellTumor Cell InvasionTumor InvasionTumor Suppressor ProteinsXenograftXenograft ModelXenograft procedureXenotransplantationalpha-Glucan Phosphorylasesanaloganti-cancer therapycancer cellcancer metastasiscancer therapycancer-directed therapycartilage link proteincell growthcolon cancer cell linecolon cancer patientscolon neoplasiacolorectal cancer cell linecolorectal cancer metastasiscolorectal cancer patientscolorectal neoplasiacombination therapycombined modality treatmentcombined treatmentcultured cell linedemographicsdetermine efficacydiffuseddiffusesdiffusingdiffusionsdrug interventiondrug treatmentdrug/agentefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationevaluate efficacyexamine efficacyexperimentexperimental researchexperimental studyexperimentsgenetic regulatory proteingenome mutationheavy metal Pbheavy metal leadimprovedinhibitorinterestintestine cancerkisspeptinknock-downknockdownlarge bowel neoplasmlink proteinmalignancymalignant intestine neoplasmmalignant intestine tumormethionine adenosyltransferasemethyl groupmouse modelmulti-modal therapymulti-modal treatmentmurine modelneoplasm/cancerneoplastic cellnew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetontogenyoverexpressoverexpressionpatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspleiotropic effectpleiotropismpleiotropyregulatory gene productresponseshRNAshort hairpin RNAsmall hairpin RNAsocial rolesynergismsynthetic lethal interactionsynthetic lethalitytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttumortumor cell metastasistumor growthtumor suppressorxeno-transplantxeno-transplantationxenograft transplant modelxenotransplant model
Description preview
Methylthioadenosine phosphorylase (MTAP) uniquely recycles methylthioadenosine (MTA) in humans,
maintaining near zero MTA concentrations. The discovery that MTAP-deleted (MTAP-/-) tumors are uniquely
sensitive to co-deletion of MAT2A or PRMT5 has led to intense interest in targeting MAT2A and PRMT5, a new
synthetic-lethal approach to cancer…
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