grant
MSC implantation as a treatment for developmental brain defects in craniosynostosis
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 1 Jun 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025AddressAnimal Experimental UseAnimal ExperimentationAnimal ModelAnimal Models and Related StudiesAnimal ResearchAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBehaviorBehavioralBiocompatible MaterialsBiological MarkersBiomaterialsBirthBleedingBlood VesselsBone-Derived Transforming Growth FactorBrainBrain Nervous SystemCalvariaCell BodyCell Communication and SignalingCell SignalingCellsCerebrospinal FluidCerebrovascular CirculationChotzen SyndromeChronicClinicCognitiveCognitive deficitsComplexCongenital DisordersCranial SuturesCraniosynostosisDataDefectDevelopmentDiseaseDisorderDrainageDrainage procedureDysfunctionDysmorphologyElevated Intracranial PressureEncephalonExhibitsFunctional disorderGLI Family GeneGLI Family ProteinGLI ProteinGLI geneGLI1GLI1 GeneGLI1 ProteinGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGlioma Associated Oncogene Homolog 1 ProteinGlioma Associated Oncogene Homolog ProteinGlioma-Associated Oncogene HomologGlioma-associated oncogeneGoalsGrowthHemorrhageHomolog of Drosophila TWIST 1Homolog of Drosophila TWIST1HumanIQ DeficitImageImpairmentImplantIntracellular Communication and SignalingIntracranial HypertensionIntracranial Pressure ElevationIntracranial Pressure IncreaseJoint structure of suture of skullKnowledgeLeadLymphatic functionMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMeningealMeningeal circuitMeningeal lymphatic networkMeningeal lymphatic pathwayMeningeal lymphatic systemMeningeal lymphaticsMeningesMesenchymal Progenitor CellMesenchymal Stem CellsMesenchymal progenitorMesenchymal stromal/stem cellsMiceMice MammalsMilk Growth FactorModern ManMurineMusMutant Strains MiceNMR ImagingNMR TomographyNamesNatural regenerationNeurocognitiveNeurocognitive DeficitNeurologicNeurologic DeficitNeurologic ModelsNeurologicalNeurological ModelsNuclear Magnetic Resonance ImagingOperative ProceduresOperative Surgical ProceduresOutcomeParturitionPathologicPatientsPb elementPhysiopathologyPlatelet Transforming Growth FactorPositionPositioning AttributePrevalenceProgenitor CellsPublishingRecurrenceRecurrentRegenerationRejuvenationReoperationRepeat SurgeryRisk FactorsSignal TransductionSignal Transduction SystemsSignalingSiteSkullStructural defectStructural malformationStructureSurgicalSurgical InterventionsSurgical ProcedureSurgical suturesSuturesSæthre-Chotzen syndromeTGF BTGF-betaTGF-βTGFbetaTGFβTWIST geneTWIST1TWIST1 geneTestingTherapeuticTissue GrowthTranscription Factor Proto-OncogeneTranscription Factor TWISTTranscription factor genesTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneValidationZeugmatographyabnormal brain functionacrocephalosyndactly type IIIacrocephalosyndactyly IIIanimal experimentationsbio-markersbiologic markerbiological materialbiological signal transductionbiomarkerblood Pbblood flow in brainblood leadblood lossbonebrain blood circulationbrain blood flowbrain dysfunctionbrain impairmentbrain volumecalvarialcerebral blood flowcerebral circulationcerebral spinal fluidcerebral veincerebral venouscerebrocirculationcerebrovascular blood flowclinical practiceclinical translationclinically translatablecognitive defectsconstrictioncraniofacial disordercraniumdetermine efficacydevelop therapydevelopmentaldrivingdysfunctional braindysostosis craniofacialis with hypertelorismeffective therapyeffective treatmentefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationevaluate efficacyexamine efficacyglioma associated oncogene 1glioma associated oncogene family zinc finger 1heavy metal Pbheavy metal leadimagingimplantationimprovedinnovateinnovationinnovativeintelligence quotient deficitintervention developmentlead in bloodlymph channellymph vessellymphatic channellymphatic vesselmeningemesenchymal stromal cellmesenchymal stromal progenitor cellsmesenchymal-derived stem cellsminimally invasivemodel of animalmouse mutantnamenamednamingneglectneurocognitive declineneurocognitive impairmentneurogenesisneuronal growthneuronal survivalnovelontogenyoperationoperationspathophysiologypre-clinicalpreclinicalprematureprematuritypreventpreventingprogenitor cell based therapyprogenitor cell therapyprogenitor cell treatmentprogenitor therapyprogenitor treatmentprognostic toolraised ICPraised intracranial pressureregeneratescaffoldscaffoldingspinal fluidstem and progenitor cell therapystem cell based therapystem cell mediated therapystem cell therapeuticsstem cell therapystem cell treatmentstem cell-based therapeuticstem cell-based treatmentstem cellsstructural abnormalitiesstructural anomaliessubstantia albasurgerysuture fusiontherapy developmenttranscription factortreatment developmenttwist proteinvalidationsvascularwhite matterwhite matter injuryyounger age
Description preview
PROJECT SUMMARY/ABSTRACT
Craniosynostosis is a craniofacial disorder, which is characterized by the premature fusion of cranial sutures with
the loss of mesenchymal stromal/stem cells (MSCs). Some craniosynostosis have neurocognitive deficits, which
are attributed to abnormally increased intracranial pression (ICP). However, the causes of ICP…
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