grant
MR1/MAIT cell axis-mediated regulation of inflammatory responses
Organization INDIANA UNIVERSITY INDIANAPOLISLocation INDIANAPOLIS, UNITED STATESPosted 15 Feb 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY2026AD dementiaAD modelAD pathologyAD patientsAddressAdoptive TransferAffectAgeAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's disease modelAlzheimer's disease pathologyAlzheimer's disease patientAlzheimer's pathologyAlzheimer's patientAlzheimers DementiaAmentiaAmmon HornAmyloid (Aβ) plaquesAmyloid PlaquesAntigen PresentationAntigen-Presenting CellsAstrocytesAstrocytusAstrogliaBody SystemBrainBrain Nervous SystemBrain PathologyCNS DiseasesCNS Nervous SystemCNS disorderCTLA-8CTLA-8 GeneCTLA8CTLA8 GeneCell BodyCell CountCell NumberCell SurvivalCell ViabilityCell-Mediated Lympholytic CellsCellsCentral Nervous SystemCentral Nervous System DiseasesCentral Nervous System DisordersCessation of lifeCornu AmmonisCytolytic T-CellCytotoxic T CellCytotoxic T-Lymphocyte-Associated Antigen 8Cytotoxic T-Lymphocyte-Associated Antigen 8 GeneCytotoxic T-Lymphocyte-Associated Serine Esterase 8Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 GeneCytotoxic T-LymphocytesDataDeathDementiaDevelopmentDifferences between sexesDiffers between sexesDiseaseDisorderDisseminated SclerosisElderlyEncephalonFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryHippocampusHistocompatibility ComplexHistocompatibility ComplicesHortega cellHumanIL-17IL-17 GeneIL-17AIL-17A GeneIL17IL17 ProteinIL17 geneIL17AIL17A GeneImmuneImmune systemImmunesInfiltrationInflammationInflammatoryInflammatory ResponseInnate Immune ResponseInnate ImmunityInterleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) GeneInterleukin 17 PrecursorInterleukin 17 Precursor GeneInterleukin-17KO miceKnock-out MiceKnockout MiceLiverMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMajor Histocompatibility ComplexMajor Histocompatibility ComplicesMediatingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMiceMice MammalsMicrogliaMicroscopyModern ManMononuclearMouse StrainsMucosaMucosal TissueMucous MembraneMultiple SclerosisMurineMusNMR ImagingNMR TomographyNative ImmunityNatural ImmunityNeuraxisNeuritic PlaquesNeurobionNon-Specific ImmunityNonspecific ImmunityNuclear Magnetic Resonance ImagingNull MouseOrgan SystemPathogenesisPathogenicityPathologyPatientsPeripheral Nervous SystemPersonsPlayPrimary Senile Degenerative DementiaProductionProliferatingProteinsReceptor ProteinRegulationReporterReportingRoleSenile PlaquesSex DifferencesSexual differencesT-CellsT-LymphocyteTemporal LobeTimeTissue SampleTouchTouch sensationUnited StatesVitamin BVitamin B ComplexWild Type MouseWorkZeugmatographyaccessory celladvanced ageagesalzheimer modelamyloid beta plaqueamyloid-b plaqueastrocytic gliaaβ plaquesbrain cellcell typecognitive assessmentcognitive performancecognitive testingcored plaquecytokinedefined contributiondevelopmentaldiffuse plaqueelderly patientflow cytophotometrygeriatricgitter cellhepatic body systemhepatic organ systemhippocampalinsular sclerosisinterestkiller T cellmesogliamicrobialmicroglial cellmicrogliocytemouse modelmurine modelneural inflammationneuroinflammationneuroinflammatoryneuropathologicneuropathologicalneuropathologynew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapy approachesnew therapy targetnew treatment approachnew treatment strategynovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapy approachnovel therapy targetobject recognitionolder patientpatient living with Alzheimer's diseasepatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseasepatients with ADperivascular glial cellprimary degenerative dementiapromoterpromotorreceptorreceptor expressionsenile dementia of the Alzheimer typesenior citizensex based differencessex-dependent differencessex-related differencessex-specific differencessocial roletactile sensationtemporal cortexthymus derived lymphocytewildtype mouse
Description preview
Alzheimer’s disease (AD) is a rapidly growing and serious worldwide malady, which is currently the most
common cause of dementia in patients of advanced age. A major contributor to the brain pathology that is
observed in AD patients is neuroinflammation, of which innate immunity plays a critical role. One component
of the innate immune response…
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