grant
Mosquito Immune Responses and Malaria Transmission
Organization NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY202570kDa heat-shock cognate proteinA. aegyptiAdes aegyptiAe. AegyptiAedes aegyptiAffectAffinityAnophelesAnopheles GenusAnopheles gambiaeAnophelinesBindingBody TissuesBreakbone Fever VirusCell BodyCellsCellular biologyCommunicationCulicidaeCytolysisDENVDENV infectionDengue InfectionDengue VirusDengue fever virusDengue virus infectionDigestionDissociationDistantDouble-Stranded RNAEnvelope ProteinEpithelial CellsExhibitsExpression SignatureFalciparum MalariaFemaleGI microbiotaGastrointestinal microbiotaGene Expression ProfileGene TranscriptionGenesGenetic DiversityGenetic PolymorphismGenetic TranscriptionGenetic VariationGlycoproteinsGoalsHaplotypesHemocytesHeterozygoteHsc70 proteinImageImmobilizationImmuneImmune memoryImmune responseImmune systemImmunesImmunityImmunologic MemoryImmunological MemoryIndividualInfectionInjectionsInsect VectorsInsectaInsectsInsects InvertebratesKineticsKnock-outKnockoutLutzomyiaLutzomyia genusLysisMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMedicalMethodologyMexicoMidgutMitochondriaMolecularMolecular InteractionMosquitoesNatural SelectionsNatureNon-Polyadenylated RNAOceaniaOocystsOrganismOrthologOrthologous GeneP vivaxP. vivaxParasitesPathway interactionsPhagocytosisPhylogenetic AnalysisPhylogeneticsPlasmodiumPlasmodium bergheiPlasmodium falciparum MalariaPlasmodium vivaxPopulationPost-Transcriptional Gene SilencingPrevalenceProcessProgenitor CellsProliferatingProteinsProtocolProtocols documentationPublishingRNARNA DegradationRNA ExpressionRNA Gene ProductsRNA InterferenceRNA NucleasesRNA SilencingRNAiRNaseReceptor ProteinRecombinantsRibonuclease Family ProteinRibonucleasesRibonucleic AcidSamplingSequence-Specific Posttranscriptional Gene SilencingSerotypingSignal PathwaySolventsSoutheast AsiaSoutheastern AsiaStructureSurfaceSurface Plasmon ResonanceTimeTissuesTranscriptionTripcellimTrypsinVirionVirus ParticleWorkanamnestic reactionanti-viral immunityantiviral immunitycell biologyclathrin uncoating proteincommunicable disease transmissiondefense responsedengue viral infectiondisease transmissiondsRNAenteric microbial communityenteric microbiotaenv Antigensenv Gene Productsenv Polyproteinsenv Proteingastrointestinal microbial floragene expression patterngene expression signaturegeographic populationgut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiotagut microbioticgut microfloraheat-shock cognate 70 proteinheterozygosityhost responseimagingimmune system responseimmunoresponseinfectious disease transmissionintestinal floraintestinal microbiotaintestinal microfloraintestinal tract microfloraliving systemmRNA Expressionmalaria infectionmalaria transmissionmalaria-infectedmalarial infectionmitochondrialnovelorthopedic freezingpathwayphysiological defense responsepolymorphismpreventpreventingprogenitorprogenitor cell proliferationprogenitor proliferationprotein Ereceptorresponserodent plasmodiascRNA sequencingscRNA-seqsecondary immune responsesingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingstem and progenitor cell proliferationstem cell proliferationstem cellstranscriptional profiletranscriptional signaturevector♀
Description preview
We discovered a novel cellular response of midgut progenitors (stem cells and enteroblasts) to Plasmodium berghei infection in Anopheles stephensi. We found that the presence of developing oocysts triggers proliferation of midgut progenitors that is modulated by the Jak/STAT pathway and is proportional to the number of oocysts on individual…
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