grant
Monoallelically expressed genes as a novel mechanism of genetic errors of immunity
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 8 Apr 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY20260-11 years oldAffectAllelesAllelomorphsAutomobile DrivingAutoregulationBioinformatics coreBioinformatics research coreBioinformatics resource coreBiologicalBlood CellsCatalogsCell BodyCell Culture TechniquesCell FractionCellsChildChild YouthChildren (0-21)ChromatinClinical ManagementDNA MethylationDNA mutationDataData SetDevelopmentDiseaseDisease ManagementDisorderDisorder ManagementDissectionDysfunctionEnvironmental FactorEnvironmental Risk FactorEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFamilyFunctional disorderGene AlterationGene ExpressionGene MutationGene TranscriptionGenesGeneticGenetic ChangeGenetic DiseasesGenetic ImprintingGenetic TranscriptionGenetic defectGenetic mutationGenomic ImprintingGenotypeGoalsHereditaryHeterogeneityHeterozygoteHistone AcetylationHomeostasisIdentical TwinsImmuneImmune systemImmunesImmunityIndividualInheritedJAK1JAK1 geneJAK1 proteinJAK1AJak1 kinaseJanus kinase 1Lineage TracingLinkLymphatic cellLymphocyteLymphocyticLyonizationM PhaseMaintenanceMendelian diseaseMendelian disorderMendelian genetic disorderMitochondrial DNAMitosisMitosis StageMitoticMolecularMonozygotic twinsMorbidityMutateMutationNaturePLCG2PLCG2 geneParental ImprintingParentsPatientsPenetrancePeripheral Blood CellPhenotypePhosphatidylinositol-Specific Phospholipase CPhospholipase C Gamma 2Physiological HomeostasisPhysiopathologyPrimary ImmunodeficiencyProcessProteinsRNA ExpressionRegulationRoleSamplingSingle-Gene DefectSomatic MutationT-CellsT-LymphocyteTestingTimeTranscriptTranscriptionTyrosine-Protein Kinase JAK1VariantVariationX InactivationX-Chromosome Inactivationautosomebiologiccalcium fluxcalcium mobilizationcatalogcell culturecell culturescell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcell typecellular lineage mappingcellular lineage trackingcongenital immune deficiencycongenital immunodeficiencydata integrationdata sharingdevelopmentaldisease phenotypedrivingenvironmental riskepigeneticallyexome sequencingexome-seqexperimentexperimental researchexperimental studyexperimentsgene defectgenetic conditiongenetic disordergenetic immune defectgenetic immune deficiencygenetic immunodeficiencygenome mutationheterozygosityhistone methylationinborn errors in immunityinborn errors of immunityinborn immunodeficiencyinherited immune defectinherited immune deficiencyinherited immunodeficiencykidslymph cellmembermonogenic diseasemonogenic disordermortalitymtDNAmutant allelenovelparentpathophysiologyprimary immune defectprimary immune deficiencyprogramsrelease of sequestered calcium ion into cytoplasmscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsingle-gene diseasesingle-gene disordersocial rolesomatic variantstemsynergismthymus derived lymphocyteyoungster
Description preview
Project Summary – Project 1
The transcription of autosomal genes is thought to occur from both inherited alleles, maternal and paternal.
However, it has recently become clear that approximately 1-5% of autosomal genes can be expressed from a
single allele in a random manner across the cells of a given individual. This restriction of allele…
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