grant
Molecular Repair of Diabetic Mesenchymal Stem Cells (dMSC) for Peripheral Arterial Disease
Organization CINCINNATI VA MEDICAL CENTER RESEARCHLocation CINCINNATI, UNITED STATESPosted 1 Jan 2020Deadline 30 Sept 2028
VANIHUS FederalResearch GrantFY2026ATAC sequencingATAC-seqATACseqAbnormal gaitAccelerationActivities of Daily LivingActivities of everyday lifeAddressAffectAmputationAnimalsAssay for Transposase-Accessible Chromatin using sequencingAutologousBloodBlood PlateletsBlood Reticuloendothelial SystemBlood VesselsBlood capillariesBody TissuesCancersCell AgingCell BodyCell CommunicationCell Communication and SignalingCell FunctionCell InteractionCell PhysiologyCell ProcessCell SenescenceCell SignalingCell TherapyCell-to-Cell InteractionCellsCellular AgingCellular FunctionCellular PhysiologyCellular ProcessCellular SenescenceChromatinChronicClinicalContralateralDefectDevelopmentDiabetes MellitusEndothelial CellsEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExtremitiesFunctional RegenerationFunctional impairmentFundingGait abnormalityGait disorderGait disturbancesGait dysfunctionGait impairmentGene TranscriptionGenetic TranscriptionGoalsHealth CareHindlimbHumanImmuneImmune Modulation TherapyImmune responseImmunesImmunoblottingImpairmentIn VitroIncidenceInflammationInflammatoryInjuryInnate Immune SystemIntracellular Communication and SignalingIschemiaLaser ElectromagneticLaser RadiationLasersLeadLegLimb structureLimbsMacrophageMalignant NeoplasmsMalignant TumorMarrow plateletMediatorMedicalMesenchymal Progenitor CellMesenchymal Stem CellsMesenchymal progenitorMesenchymal stromal/stem cellsMiceMice MammalsModelingModern ManMolecularMotor End-PlateMotor EndplateMurineMusMuscleMuscle AtrophyMuscle DenervationMuscle DiseaseMuscle DisordersMuscle FibersMuscle TissueMuscle denervation procedureMuscular AtrophyMuscular DiseasesMyopathic ConditionsMyopathic Diseases and SyndromesMyopathic disease or syndromeMyopathyMyotubesMφNatural regenerationNon-TrunkObesityPBSCPainPainfulPathologyPathway interactionsPatientsPb elementPerformancePerfusionPeripheral Blood Stem CellPeripheral Stem CellsPeripheral arterial diseasePeripheral blood progenitorPlateletsProcessPublicationsRNA ExpressionRecovery of FunctionRegenerationRegenerative capacityRejuvenationReplicative SenescenceResearchResolutionRhabdomyocyteRoleRunningScientific PublicationSignal TransductionSignal Transduction SystemsSignalingSkeletal FiberSkeletal MuscleSkeletal Muscle CellSkeletal Muscle FiberSkeletal MyocytesSpeedStaining methodStainsSubcellular ProcessSynapsesSynapticTestingTherapeuticThrombocytesTimeTissuesTranscriptionTranslationsVascular blood supplyVascular regenerationVeteransVoluntary MuscleWalkingWalking impairmentWestern BlottingWestern ImmunoblottingWorkadiposityage associatedage correlatedage dependentage linkedage relatedage specificangiogenassaultassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingaxon regenerationaxonal regenerationbiological signal transductionblood supplycapillarycell based interventioncell mediated interventioncell mediated therapiescell regenerationcell-based therapeuticcell-based therapycellular regenerationcellular therapeuticcellular therapyclinical translationclinically translatablecorpulencedaily living functiondaily living functionalitydensitydevelopmentaldiabetesdiabeticdiabetic patientdisabilityempowermentepigenetic regulationepigeneticallyfunctional abilityfunctional capacityfunctional recoveryfunctional restorationheavy metal Pbheavy metal leadhost responseimmune modulatory therapiesimmune modulatory treatmentimmune regulation therapyimmune regulation treatmentimmune regulatory therapyimmune system responseimmune-modulation treatmentimmunomodulation therapyimmunomodulation treatmentimmunomodulator therapiesimmunomodulator treatmentimmunomodulator-based therapiesimmunomodulatory biologicsimmunomodulatory therapiesimmunomodulatory treatmentimmunoregulatory therapyimmunoregulatory treatmentimmunoresponseimprovedin vivoin vivo Modelinflammatory environmentinflammatory milieuinjuredinjuriesinnervationinnovateinnovationinnovativemalignancymesenchymal stromal cellmesenchymal stromal progenitor cellsmesenchymal-derived stem cellsmilitary veteranmuscle breakdownmuscle degradationmuscle deteriorationmuscle lossmuscle regenerationmuscle wastingmuscularmuscular disorderneoplasm/cancernerve supplyneuromuscularneuron regenerationneuronal regenerationnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnon-diabeticnondiabeticnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathwayperipheral artery diseaseperipheral nerve regenerationprogenitor cell based therapyprogenitor cell therapyprogenitor cell treatmentprogenitor therapyprogenitor treatmentprotein blottingregenerateregeneration abilityregeneration based therapyregeneration capacityregeneration therapyregenerativeregenerative cellregenerative therapeuticsregenerative therapyreinnervatereinnervationrepairrepairedreplicative agingresolutionsresponserestore functionrestore functionalityrestore lost functionsocial rolestem and progenitor cell therapystem cell based therapystem cell mediated therapystem cell therapeuticsstem cell therapystem cell treatmentstem cell-based therapeuticstem cell-based treatmentsuccesssynapsetherapeutic immunomodulationtherapeutic immunoregulationtranslationtranslational opportunitiestranslational potentialvascularvascular supplyveteran population
Description preview
Background and Innovation: Diabetes and ischemia lead to loss of neuromotor connections resulting in
disability. Diabetic Veterans with PAD have significant therapeutic needs that are often incompletely addressed
due to limitations in our understanding and therapeutic options. Functional recovery of ischemic muscle is the
goal of this proposal.…
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