grant
Molecular Regulation of Stem Cell Aging
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 1 Jul 2011Deadline 31 May 2029
NIHUS FederalResearch GrantFY202521+ years oldAD dementiaAdultAdult HumanAffectAgeAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAstrocytesAstrocytusAstrogliaBloodBlood Reticuloendothelial SystemBody TissuesBrainBrain Nervous SystemCRISPR approachCRISPR based approachCRISPR editing screenCRISPR methodCRISPR methodologyCRISPR screenCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based screenCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 screenCRISPR/Cas9 technologyCas nuclease technologyCell BodyCellsCerebrospinal FluidChromatinClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCollaborationsDegenerative Neurologic DisordersDeteriorationDiseaseDisorderEncephalonEndothelial CellsEnvironmentExerciseExhibitsGene TranscriptionGenetic TranscriptionGoalsIn VitroIndividualIntermediary MetabolismInterventionLearningLipidsLiquid substanceMapsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMemoryMetabolicMetabolic ProcessesMetabolismMolecularNeighborhoodsNerve CellsNerve UnitNervous SystemNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural Stem CellNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Body SystemNeurologic Degenerative ConditionsNeurologic Organ SystemNeuronsOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellPrimary Senile Degenerative DementiaProgenitor CellsProteomicsRNA ExpressionRegimenRegulationRejuvenationResolutionTechnologyTestingTissuesTranscriptionWorkadulthoodage clockage reversalagedaged animalaged animalsaged brainaged miceaged mouseagesaging brainaging clocksaging reversalalleviate age relatedalleviate agingameliorating aginganimal old ageastrocytic gliacell typecerebral spinal fluidclock measuring biological ageclock measuring biological agingclock of biological agingclustered regularly interspaced short palindromic repeats screencounter age relatedcounter agingcounteract age relatedcounteract agingdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdesigndesigningdiet and exercisedietary restrictionelderly animalelderly miceepigenomeexperimentexperimental researchexperimental studyexperimentsfluidfunctional restorationgenome scalegenome-widegenomewideglobal gene expressionglobal transcription profileglucose metabolismin vivoinjury and repairliquidmachine learning based modelmachine learning modelmetabolism measurementmetabolomemetabolomicsmetabonomemetabonomicsnerve stem cellneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneurodegenerative illnessneurogenesisneurogenic progenitorsneurogenic stem cellneuron progenitorsneuronalneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuroprogenitorold animalsold miceprimary degenerative dementiaprogenitor agingprogenitor and neural stem cellsprogenitor cell agingprogenitor cell functionprogenitor cell nicheprogenitor functionprogenitor nicheprogramsregenerativerejuvenating interventionrejuvenation approachrejuvenation strategiesrejuvenation therapyrejuvenation treatmentrepairrepairedresolutionsresponserestore functionrestore functionalityrestore lost functionrestricted dietreverse agereverse agingreverse aging effectsreversible agingscRNA sequencingscRNA-seqsenile dementia of the Alzheimer typesensorsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingspatial relationshipspinal fluidstem and progenitor cell functionstem and progenitor cell nichestem and progenitor functionstem cell agingstem cell functionstem cell nichestem cellssubventricular zonesynergismtherapeutic rejuvenationtranscriptometranscriptomics
Description preview
SUMMARY
The overall goal of this project is to identify functional metabolic changes in adult neural stem cells during aging,
with the objective of `reprogramming' chromatin and transcriptional states in old stem cells and rejuvenate their
function. The adult brain contains regenerative neurogenic niches that comprise neural stem cells (NSCs).…
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