grant
Molecular Profiling and Biomarkers of Memory Phenotypes in Temporal Lobe Epilepsy
Organization CLEVELAND CLINIC LERNER COM-CWRULocation CLEVELAND, UNITED STATESPosted 15 Jul 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanAmmon HornBiologicalBiological MarkersBloodBlood PlasmaBlood Reticuloendothelial SystemBody TissuesBrainBrain Nervous SystemBrain regionCausalityCell BodyCellsClinicClinicalClinical TrialsCornu AmmonisDataData SetDegenerative Neurologic DisordersDentate FasciaDevelopmentDifferential Gene ExpressionDrug resistanceEncephalonEpilepsyEpileptic SeizuresEpilepticsEpisodic memoryEtiologyExpression SignatureFascia DentataFormalinFreezingFutureGene Expression AlterationGene Expression ProfileGene TranscriptionGenesGenetic TranscriptionGlutamatesGoalsGyrus DentatusHigh PrevalenceHippocampusL-GlutamateLanguageLateralMeasurableMemoryMemory DeficitMemory impairmentMendelian randomizationMicroRNAsModelingMolecularMolecular FingerprintingMolecular ProfilingNeocortexNerve CellsNerve DegenerationNerve UnitNervous System Degenerative DiseasesNervous System DiseasesNervous System DisorderNervous System PhysiologyNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurobiologyNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeurologic DisordersNeurologic functionNeurological DisordersNeurological functionNeuron DegenerationNeuronsOperative ProceduresOperative Surgical ProceduresParaffin EmbeddingPathogenesisPathologicPatientsPatternPerformancePeripheralPhenotypePlasmaPlasma SerumPlayProcessProspective cohortProteinsProteomePublishingQOLQuality of lifeRNA ExpressionResearchResearch ResourcesResectedResolutionResourcesReticuloendothelial System, Serum, PlasmaRoleSeizure DisorderSeriesSeverity of illnessSignal PathwaySingle-Nucleus SequencingSurgicalSurgical InterventionsSurgical ProcedureTauopathiesTemporal LobeTemporal Lobe EpilepsyTissue EmbeddingTissue-Specific Differential Gene ExpressionTissue-Specific Gene ExpressionTissuesTranscriptTranscriptionadulthoodbio-markersbiologicbiologic markerbiomarkerbiomarker identificationcandidate biomarkercandidate identificationcandidate markercausationcell typeclinical phenotypecohortdaily functioningdata integrationdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdentate gyrusdevelopmentaldifferential expressiondifferentially expresseddigitaldisease causationdisease severitydrug resistanteffective therapyeffective treatmentepilepsiaepileptogenicepisodic memory impairmentepisodic memory lossevidence basefunctional improvementgene expression patterngene expression signatureglobal gene expressionglobal transcription profileglutamatergichigh riskhippocampalhippocampal cell losshippocampal sclerosishomotypical cortexidentification of biomarkersidentification of new biomarkersimprove functionimprovedimproved functional outcomesinnovateinnovationinnovativeisocortexisolated memory lossmarker identificationmedial temporal areamedial temporal lobememory dysfunctionmemory processmemory processingmesial temporal areamesial temporal lobemiRNAmolecular biomarkermolecular markermolecular profilemolecular signatureneocorticalneopalliumnervous system functionneural degenerationneurobiologicalneurodegenerationneurodegenerativeneurodegenerative illnessneurological degenerationneurological diseaseneuronalneuronal degenerationneuropathologic tauneuropathological taunoveloverexpressoverexpressionpatient stratificationpatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypesperipheral bloodpredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerpreventpreventingprognosticationprospectiveprotein expressionregional differenceresistance to Drugresistant to DrugresolutionssNuc-Seqsingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqsocial rolestratified patientsurgerytau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau induced degenerationtau induced neurodegenerationtau mediated neurodegenerationtau neurodegenerative diseasetau neuropathologytau pathologytau pathophysiologytau proteinopathytau related neurodegenerationtau-induced pathologytauopathic neurodegenerative disordertauopathytemporal cortextranscriptional differencestranscriptional profiletranscriptional signaturetranscriptome
Description preview
PROJECT SUMMARY
Temporal lobe epilepsy (TLE) is a leading cause of seizure disorders in adults and is associated with high risk
of memory deficits that can negatively impact day-to-day functioning and quality of life. Memory deficits are most
prevalent in those with pharmacoresistant mesial TLE and hippocampal sclerosis (MTLE-HS). However, a large…
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