grant
Molecular physiology of Phox2b-expressing RTN chemoreceptor neurons
Organization UNIVERSITY OF VIRGINIALocation CHARLOTTESVILLE, UNITED STATESPosted 4 Apr 2025Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY2026AccountingAffectAlveolarAnimalsArousalAttenuatedBasal Transcription FactorBasal transcription factor genesBrain StemBrainstemBreathingCO2Candidate Disease GeneCandidate GeneCarbon DioxideCarbonic AnhydrideCell BodyCell Communication and SignalingCell DeathCell NucleusCell SignalingCellsCentral Alveolar HypoventilationCentral ApneaCentral Sleep ApneaCentral Sleep Apnea SyndromeCentral Sleep-Disordered BreathingCentral Sleep-Disordered BreathingsCessation of lifeCharacteristicsChemoreceptorsClinicalCot DeathCrib DeathDNA mutationDataDeathDevelopmentDysfunctionEEGEGR2EGR2 geneElectroencephalogramElectroencephalographyEmbryoEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic DevelopmentExperimental ModelsFunctional disorderG Protein Coupled Receptor 4GPR4GPR4 geneGene Action RegulationGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic ChangeGenetic MarkersGenetic ModelsGenetic TranscriptionGenetic defectGenetic mutationHomeo BoxesHomeoboxHumanHypoventilationInitiation FactorsIntracellular Communication and SignalingKI miceKROX20Knock-in MouseLifeLinkMedulla OblongataMiceMice MammalsModelingModern ManMolecularMurineMusMutant Strains MiceMutateMutationMyelencephalonNBPhox proteinNerve CellsNerve UnitNeural CellNeurocyteNeuronal DifferentiationNeuronsNucleusOndine SyndromePMX2B proteinPathway interactionsPeptide Initiation FactorsPhenocopyPhenotypePhox2b proteinPhysiologicPhysiologicalPhysiologyPhysiopathologyPlethysmographyPopulationPropertyRNA ExpressionReflexReflex actionRegulationRespirationRespiratory AspirationRespiratory InspirationRoleSIDSSensorySignal TransductionSignal Transduction SystemsSignalingSingle cell seqSpecific qualifier valueSpecifiedSudden Infant DeathSudden Unexpected Infant DeathSudden infant death syndromeSynapsesSynapticSyndromeSystemTestingTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTranslation Initiation FactorTranslational Initiation FactorViralWorkattenuateattenuatesbiological signal transductioncellular targetingcongenital central hypoventilation syndromedetectordevelopmentalexcitatory neurongene biomarkergene expression biomarkergene manipulationgene markergene signature biomarkergenetic biomarkergenetic manipulationgenetically manipulategenetically perturbgenome mutationglobal gene expressionglobal transcription profileinspirationknock-downknockdownknockin micemolecular phenotypemouse geneticsmouse modelmouse mutantmurine modelmutantnecrocytosisneuronalneuropathologicneuropathologicalneuropathologynovelpaired mesoderm homeobox 2bpathophysiologypathwaypolyalaninepost-synaptic nervespost-synaptic neuronspostnatalpostsynapticpostsynaptic nervespostsynaptic neuronsprogramsrespiratoryrespiratory mechanismresponsescRNA sequencingscRNA-seqsensorsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell next generation sequencingsingle cell sequencingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesynapsetooltranscription factortranscription factor Phox2btranscriptometranscriptomics
Description preview
PROJECT SUMMARY
A discrete group of intrinsically CO2/H+-sensitive brainstem neurons located in the retrotrapezoid nucleus (RTN)
provide a critical state-dependent and CO2-modulated excitatory drive to respiratory and arousal circuits. RTN
dysfunction is implicated in various syndromes associated with reduced arousal and ventilatory responses to…
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