grant

Molecular Phenotyping of ARDS, Pneumonia, and Sepsis using Latent Class Analysis and Metagenomic Sequencing

Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 May 2023Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY202521+ years oldARDSActive Follow-upAcute Respiratory DistressAcute Respiratory Distress SyndromeAddressAdultAdult ARDSAdult HumanAdult RDSAdult Respiratory Distress SyndromeAreaAsthmaBiologicalBloodBlood Reticuloendothelial SystemBreast CancerBronchial AsthmaCaliforniaCancersClassificationClinicalClinical DataClinical ResearchClinical StudyClinical TrialsCollectionConduct Clinical TrialsCritical CareCritical IllnessCritically IllDa Nang LungDataData SetDevelopmentDiagnosisDiagnosticDrug TherapyEnrollmentFailureFunctional MetagenomicsFutureGeneral HospitalsGeneral TaxonomyGoalsHR positiveHeterogeneityHistoryInflammatoryIntervention TrialInterventional trialInvestigatorsKnowledgeLeadLeadershipLong-term cohort studyLongitudinal cohort studyMalignant Breast NeoplasmMalignant NeoplasmsMalignant TumorMechanical ventilationMetagenomicsMicrobeMorbidityMorbidity - disease rateNHLBINational Heart, Lung, and Blood InstituteObservation researchObservation studyObservational StudyObservational researchOut-patientsOutcomeOutpatientsParticipantPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPb elementPharmacological TreatmentPharmacotherapyPhenotypePlasma ProteinsPneumoniaPopulationPopulation HeterogeneityProspective StudiesRecording of previous eventsResearch PersonnelResearchersResolutionSamplingSan FranciscoSeaSepsisShock LungSiteStiff lungSurvivorsSyndromeSystematicsTamoxifenTaxonomyTherapeuticTracheaTrachea ProperUniversitiesWorkactive followupadulthoodaspiratebiologicbiological heterogeneityclinical centerclinical databaseclinical heterogeneitycohortdesigndesigningdevelopmentaldiagnostic criteriadiverse populationsdrug interventiondrug treatmentenrollfollow upfollow-upfollowed upfollowupheavy metal Pbheavy metal leadheterogeneous populationhistorieshormone receptor +hormone receptor-positiveimprovedimproved outcomeinsightmalignancymalignant breast tumormechanical respiratory assistmechanically ventilatedmetagenome sequencingmetagenomic sequencingmicrobialmicrobiomemolecular phenotypemortalityneoplasm/cancernew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyobservational cohort studypathogenpathwaypatient oriented outcomespatient populationpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspopulation diversityprecision medicineprecision-based medicineprognosticprognostic abilityprognostic powerprognostic utilityprognostic valueprospectiveprotein biomarkersprotein markersresolutionsresponse to therapyresponse to treatmenttargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic responsetherapeutic targettherapy responsetraittreatment responsetreatment responsivenesswet lungwindpipe
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ABSTRACT
This application to RFA HL-23-001 proposes a California Clinical Center for participation in the Acute

Respiratory Distress Syndrome (ARDS), Pneumonia, and Sepsis (APS) Consortium study. Our Clinical Center

consists of 4 sites: University of California, San Francisco (UCSF; lead site); UCSF Fresno; Zuckerberg San

Francisco General…

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