grant
Molecular modulator of RAD51 in maintaining genome stability
Organization ROSALIND FRANKLIN UNIV OF MEDICINE & SCILocation NORTH CHICAGO, UNITED STATESPosted 1 Dec 2019Deadline 31 Dec 2029
NIHUS FederalResearch GrantFY2025Advanced CancerAdvanced Malignant NeoplasmAntiphosphopeptide-Specific AntibodiesAssayAutomobile DrivingBRCA2BRCA2 geneBindingBinding ProteinsBinding SitesBioassayBiochemicalBiological AssayBreast Cancer 2 GeneBreast Cancer Type 2 Susceptibility GeneCUT&RUNCalciumCalcium Ion SignalingCalcium SignalingCancer BiologyCancer TreatmentCancersCell BodyCell DeathCell SurvivalCell ViabilityCellsCellular biologyCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseColorCombining SiteCompensationComplexCryo-electron MicroscopyCryoelectron MicroscopyDNADNA ReplicationDNA SynthesisDNA biosynthesisDNA lesionDNA mutationDNA replication forkDataDeoxyribonucleic AcidDiseaseDisorderEarly Onset Gene Breast Cancer 2Electron CryomicroscopyElectronicsEnsureFANCD1FundingGenetic ChangeGenetic defectGenetic mutationGenome InstabilityGenome StabilityGenomic InstabilityGenomic StabilityGenomicsGoalsHereditary Breast Cancer 2ImpairmentIntrinsic factorLigand Binding ProteinLigand Binding Protein GeneMaintenanceMalignant CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMapsMediatingMicroscopyModelingMolecularMolecular InteractionMutationPARP InhibitorPARP-1 inhibitorPARPiPathway interactionsPhospho-Specific AntibodiesPhosphopeptide-Specific AntibodiesPhosphorylationPhosphorylation State-Specific AntibodiesPhosphospecific AntibodyPlayPoly(ADP-ribose) Polymerase InhibitorPoly(ADP-ribose) polymerase 1 inhibitorPredispositionProcessProtein BindingProtein PhosphorylationProteomicsPublic HealthReactive SiteResearchResistanceResolutionRoleShapesSignal PathwaySingle-Stranded DNASiteStress Response SignalingStructureSusceptibilityTechniquesTechnologyTestingTumor Suppressor Proteinsanti-cancer therapybound proteinbrca 2 genecancer cellcancer initiationcancer progressioncancer therapycancer-directed therapycell biologycryo-EMcryoEMcryogenic electron microscopydrivingdriving forceelectronicelectronic deviceenvironmental agentgenome integritygenome mutationgenome scalegenome-widegenomewidegenomic integrityimprovedinnovateinnovationinnovativeinsightmalignancynecrocytosisneoplasm progressionneoplasm/cancerneoplastic progressionnovelnucleasepathwaypreservationpreventpreventingprotein complexrecruitreplication forkreplication stressresistantresolutionsresponsesocial rolessDNAtumor progressiontumor suppressor
Description preview
Genome instability is a hallmark of cancer progression, often exacerbated by replication stress that stalls and
disrupts DNA replication, threatening cell survival. Cells use intricate and tightly regulated mechanisms to
prevent improper degradation of stalled replication forks by nucleases, a process critical for preserving the
genome integrity.…
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