grant
Molecular Mechanisms Regulating Calcium Flux In Salivary Glands
Organization NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCHLocation UNITED STATES
NIHUS FederalResearch GrantFY2025AdoptedAffectAffinityAgonistAmino Acid SequenceAmino Acid Sequence AnalysesAmino Acid Sequence AnalysisAmino AcidsAsialiaAutophagocytosisBackBindingBinding ProteinsBiophysicsCalciumCancersCariesCell BodyCell Communication and SignalingCell SignalingCell membraneCellsCharacteristicsChargeConsensus SequenceCytoplasmic MembraneDNA mutationDataDeglutition DisordersDental DecayDental cariesDorsumDoseDysfunctionDysphagiaEF Hand MotifsEF HandsEF-Hand Calcium-Binding MotifEF-Hand DomainEnvironmentFluids and SecretionsFunctional disorderGenerationsGenetic ChangeGenetic defectGenetic mutationGeometryGlandGoalsHourHydrolysisHyposalivationIntracellular Communication and SignalingIonsLigand Binding ProteinLigand Binding Protein GeneLiquid substanceMaintenanceMalignant NeoplasmsMalignant TumorMediatingMiceMice MammalsMitochondriaMolecularMolecular ConfigurationMolecular ConformationMolecular Dynamics SimulationMolecular InteractionMolecular StereochemistryMorphologyMouth DrynessMurineMusMutationN-terminalNH2-terminalNerve Transmitter SubstancesNeurotransmittersOral healthOsmosisPIP2Peptide Sequence AnalysesPeptide Sequence AnalysisPhenotypePhosphatidylinositol 4,5-BiphosphatePhosphatidylinositol 4,5-DiphosphatePhosphatidylinositol-4,5-BisphosphatePhysiologicPhysiologicalPhysiopathologyPlasma MembranePlayPositionPositioning AttributePrimary Protein StructurePropertyProtein BindingProtein Sequence AnalysesProtein Sequence AnalysisProteinsPtIns 4,5-P2PtdInsP2RegulationReportingResearchRestRoleSAM DomainSTIM1STIM1 geneSalivaSalivary GlandsSalivary hypofunctionSeriesSignal TransductionSignal Transduction SystemsSignalingSterile Alpha MotifSterile Alpha Motif DomainStimulusStromal Interaction Molecule 1StructureSuggestionSwallowing DisordersTimeTubularTubular Aggregate MyopathiesTubular formationXerostomiaXerostomicaminoacidaptyalismautophagybiological signal transductionbiophysical characteristicsbiophysical characterizationbiophysical foundationbiophysical measurementbiophysical parametersbiophysical principlesbiophysical propertiesbiophysical sciencesbound proteincalcium fluxcalcium mobilizationchelationcomparativeconformationconformationalconformational stateconformationallyconformationsdental healthdesigndesigningdry mouthfluidgenome mutationinfection mouthinsightirradiationliquidmalignancymitochondrialmolecular dynamicsmonomermouse modelmurine modelmutantneoplasm/cancernoveloral drynessoral infectionoral infectiouspathophysiologyplasmalemmapreventpreventingprotein sequencerecruitrelease of sequestered calcium ion into cytoplasmresponsesalivary gland hypofunctionsenescencesenescentsensorsocial rolethermolabilitythermostabilitytooth decay
Description preview
Research Advances
Our key findings in this fiscal year are as follows:
1.STIM proteins, STIM1 and STIM2, play important roles in the activation of store-operated calcium entry (SOCE) through their interaction with the plasma membrane Ca2+ channel, Orai1. Unlike STIM1, STIM2 can sense small decreases in ER-Ca2+ levels, such as those induced at…
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