grant

Molecular Mechanisms of Tubulin Polymerization Promoting Protein in Mitochondrial Function and Neuronal Survival

Organization UNIVERSITY OF TEXAS HLTH SCIENCE CENTERLocation SAN ANTONIO, UNITED STATESPosted 1 Jul 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY202521+ years oldAD related dementiaADRDAddressAdultAdult HumanAffectAgeAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAmpullary CrestAssayAutopsyBehavioralBioassayBiochemicalBioenergeticsBiologic ModelsBiologicalBiological AssayBiological ModelsBrainBrain Nervous SystemBrain regionCarrier ProteinsCell BodyCellsCharacteristicsChemical FractionationCitric Acid CycleCo-ImmunoprecipitationsComplexCrista ampullarisCytoplasmDA NeuronDNA mutationDataData AnalysesData AnalysisDegenerative Neurologic DisordersDiseaseDisorderDopamine neuronDrosophilaDrosophila genusDysautonomia-Orthostatic Hypotension SyndromeDysautonomic Orthostatic HypotensionDysfunctionEconomicsElectron TransportEncephalonFRACNFamilyFliesFractionationFractionation RadiotherapyFunctional disorderFundingFutureGeneHomologGenesGeneticGenetic ChangeGenetic defectGenetic mutationHealthHealth CareHomologHomologous GeneHomologueHumanImmunoblottingIndividualInner mitochondrial membraneKnowledgeKrebs CycleLB dementiaLC/MSLewy Body DementiaLewy Body Type Senile DementiaLewy dementiaMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMembrane PotentialsMethodologyMethodsMitochondriaModel SystemModelingModern ManMolecularMorphologyMultiple System AtrophyMultiple System Atrophy SyndromeMultisystem AtrophyMultisystemic AtrophyMutationNINDSNamesNational Institute of Neurological Diseases and StrokeNational Institute of Neurological Disorders and StrokeNerve CellsNerve DegenerationNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationNeuronsOutcomes ResearchParalysis AgitansParietal LobeParkinsonParkinson DiseasePathogenesisPathogenicityPathologyPatientsPersonsPhenocopyPhysiopathologyPolymersPreparationPrimary ParkinsonismProgressive Autonomic FailureProteinsProteomicsResearchResting PotentialsRisk-associated variantRoleShy-Drager SyndromeShy-Drager Type Idiopathic Orthostatic HypotensionSpirometrySubstantia NigraSubstantia nigra structureSuperoxide AnionSuperoxide RadicalSuperoxidesSystemTCA cycleTechniquesTestingTimeTransmembrane PotentialsTransport Protein GeneTransport ProteinsTransporter ProteinTricarboxylic Acid CycleTubulinWestern BlottingWestern Immunoblottingadulthoodagesbiologicbrain tissuecrista ampullacristaedata interpretationdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdensitydesigndesigningdisabilitydopaminergic neuroneconomiceffective therapyeffective treatmentelectron transferexperimentexperimental researchexperimental studyexperimentsflyfruit flygel electrophoresisgene locusgenetic approachgenetic locusgenetic strategygenome mutationgenomic locationgenomic locusin vivoinsightinsoluble aggregateiodixanolknock-downknockdownliquid chromatography mass spectrometrymembermitochondrialmitochondrial membranemutantnamenamednamingnecropsynerve cell deathnerve cell lossneural degenerationneurodegenerationneurodegenerativeneurodegenerative illnessneurological degenerationneuron cell deathneuron cell lossneuron deathneuron lossneuronalneuronal cell deathneuronal cell lossneuronal deathneuronal degenerationneuronal lossneuronal survivalnoveloverexpressoverexpressionparietal cortexpathophysiologypharmacologicpolymerpolymericpolymerizationpostmortempreparationspreventpreventingprogramsprogressive neurodegenerationprotein aggregateprotein aggregationprotein blottingprotein functionrisk allelerisk generisk genotyperisk locirisk locusrisk variantsexsocial rolesolutesynucleinopathytherapeutic target
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ABSTRACT
Parkinson’s disease (PD), Alzheimer’s disease and related dementias (AD/ADRD) are debilitating progressive
neurodegenerative diseases. These diseases have no effective treatments currently and are among the greatest
unmet challenges in healthcare today affecting millions of people globally with enormous economic and societal
burdens.…

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Molecular Mechanisms of Tubulin Polymerization Promoting Protein in Mitochondrial Function and Neuronal Survival — UNIVE | Dev Procure