grant
Molecular mechanisms of sympatho-excitation in cardiovascular disease
Organization UNIVERSITY OF NEVADA RENOLocation RENO, UNITED STATESPosted 1 Jul 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025AddressAnimal ModelAnimal Models and Related StudiesAttentionAutonomic nervous systemAutoregulationAxonBlood PlasmaCNS Nervous SystemCVD preventionCardiacCardiac ChronotropismCardiac Muscle CellsCardiac MyocytesCardiac OutputCardiac infarctionCardiocyteCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular ModelsCardiovascular Organ SystemCardiovascular systemCause of DeathCell BodyCellsCentral Nervous SystemCharacteristicsChemicalsCo-cultureCocultivationCocultureCoculture TechniquesCommon Rat StrainsControl AnimalDiseaseDisease ProgressionDisorderEarly DiagnosisEfferent PathwaysExhibitsFluorescence Light MicroscopyFluorescence MicroscopyFoundationsFrequenciesGoalsGrantHeartHeart Muscle CellsHeart RateHeart VascularHeart failureHeart myocyteHomeostasisHyperactivityImaging ProceduresImaging TechnicsImaging TechniquesInbred SHR RatsInflammationInvestigatorsLevarterenolLevonorepinephrineLocationMeasuresMicroscopyMolecularMolecular MotorsMuscle CellsMyocardial InfarctMyocardial InfarctionMyocytesNa elementNeonatalNerve CellsNerve Transmitter SubstancesNerve UnitNeural CellNeuraxisNeurocyteNeuronsNeuropeptide TyrosineNeuropeptidesNeurotransmittersNociceptorsNoradrenalineNorepinephrineOrganOutcomePathogenesisPathologicPathologyPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatternPerfusionPeripheralPhysiological HomeostasisPlasmaPlasma SerumPlayPreparationRatRats MammalsRattusRegulationRenal functionReportingResearchResearch PersonnelResearchersResolutionReticuloendothelial System, Serum, PlasmaRiskSHR RatsSodiumSpontaneously Hypertensive RatsStructure of superior cervical ganglionSuperior Cervical GanglionSympathetic Nervous SystemSynapsesSynapticSystemTechniquesTestingTherapeutic InterventionTimeVaricesVaricose VeinsVaricosityVentricularVesicleVisualizationcardiac disease preventioncardiac failurecardiac infarctcardiomyocytecardiovascular disease preventioncardiovascular disease riskcardiovascular disordercardiovascular disorder preventioncardiovascular disorder riskchemotherapycirculatory systemcoronary attackcoronary infarctcoronary infarctionearly detectionfightingheart attackheart infarctheart infarctionheart outputhypertensiveinnervationinnovateinnovationinnovativeinsightintervention therapykidney functionlive cell imagelive cell imaginglive cell microscopylive cellular imagelive cellular imagingmodel of animalnerve supplyneurogenic hypertensionneuronalneuropathic painneuropeptide Ynew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnociceptive neuronsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachpain-sensing neuronspain-sensing sensory neuronspain-sensing somatosensory neuronspainful neuropathypatient oriented outcomespotential biological markerpotential biomarkerpreparationsresolutionsresponsespontaneous hypertensive ratsudden cardiac deathsuperresolution microscopysynapsetargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttraffickingvascular constrictionvasoconstrictionvoltage
Description preview
Project summary/abstract
Cardiovascular disease is the leading cause of death worldwide, and overactivity of the sympathetic branch of
the autonomic nervous system (sympatho-excitation) plays a key role in the pathogenesis or progression of
numerous cardiovascular diseases. Overactivity of cardiac sympathetic neurons leads to increased release of…
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