grant
Molecular mechanisms of somatosensory adaptation to prolonged hypothermia
NIHUS FederalResearch GrantFY2025AccelerationAction PotentialsActive Follow-upAffectAfferent NeuronsAnimalsAttenuatedBiologicalBiophysicsBody TemperatureCell BodyCell Communication and SignalingCell SignalingCellsCellular MechanotransductionCitellusCyclicityDataDetectionDevelopmentDorsal Root GangliaDropsDysfunctionElectrophysiologyElectrophysiology (science)EventExposure toFire - disastersFiresFunctional disorderGangliaGleanGoalsHibernationHistologyHumanHypothermiaIntracellular Communication and SignalingIon ChannelIon Channel GatingIon Channel GatingsIonic ChannelsK channelLightMammaliaMammalsMechanical Signal TransductionMechanicsMechanoreceptorsMechanosensory TransductionMediatingMedicalMembrane ChannelsMiceMice MammalsModelingModern ManMolecularMolecular TargetMurineMusNerveNerve CellsNerve UnitNeural CellNeural GanglionNeurocyteNeuronsNeuropathyNeurophysiology / ElectrophysiologyPainPainfulPalliative CarePalliative TherapyPalliative TreatmentPathologicPathway interactionsPeriodicityPeripheralPeripheral NervesPharmacologyPhenotypePhotoradiationPhysiologicPhysiologicalPhysiologyPhysiopathologyPiezo 2Piezo 2 ion channelPiezo2PopulationPotassium ChannelPotassium Ion ChannelsPreparationProcessPropertyRhythmicityRoleSensorySensory NeuronsSignal TransductionSignal Transduction SystemsSignalingSkinSodium ChannelSodium Ion ChannelsSpermophilusSpinal GangliaSquirrelStimulusSuslikSystemTemperatureTestingTouchTouch sensationUpregulationVoltage-Gated K+ ChannelsVoltage-Gated Potassium Channelactive followupafter strokealleviate symptomameliorating symptomanimationassociated symptomattenuateattenuatesbiologicbiological signal transductionbiophysical analysisbiophysical foundationbiophysical principlesbiophysical sciencesbiophysical studieschemotherapyclinical practiceco-morbid symptomco-occuring symptomcold temperaturecomfort carecomorbid symptomconcurrent symptomcooccuring symptomdecrease symptomdevelopmentaldorsal root ganglionelectrophysiologicalexperimentexperimental researchexperimental studyexperimentsfewer symptomsfirefollow upfollow-upfollowed upfollowupground squirrelimprovedinsightlow temperaturemechanicmechanicalmechanical allodyniamechanical forcemechanical stimulusmechanosensingmechanotransductionmodel organismnatural hypothermianerve damagenerve injuryneural injuryneuronalneuropathicneuropathic painnovelpainful neuropathypalliative interventionpatch clamppathophysiologypathwaypost strokepoststrokepreparationspreservationreduce symptomsrelieves symptomsresponsesocial rolesomatosensorysymptom alleviationsymptom associationsymptom comorbiditysymptom reductionsymptom relieftactile sensationtrue squirrelvibrationvirtualvoltage
Description preview
Project Summary/Abstract
Mechanosensitivity and mechanotransduction are fundamental processes that affect virtually all aspects of
human physiology. Sensitivity to mechanical stimuli ranges from light touch to unpleasant or painful and relies
on the ability of primary sensory afferents to transduce these stimuli into electrical signaling. In…
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