grant
Molecular mechanisms of post-transplant recurrent alcoholic liver disease
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 10 Sept 2017Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026AblationAbsolute ethanolAlcohol Chemical ClassAlcoholicAlcoholic Liver DiseasesAlcoholic steatohepatitisAlcoholsAssayAutoregulationBasal Transcription FactorBasal transcription factor genesBioassayBiochemicalBiogenesisBiologic ModelsBiological AssayBiological MarkersBiological ModelsBiologyBlood SerumBody TissuesBoozerCell BodyCell Communication and SignalingCell SignalingCellsCeramidesChronicCirrhosisComplexDataDependent drinkerDevelopmentDietDiseaseDisorderETOHEarly DiagnosisEarly identificationEnergy ExpenditureEnergy MetabolismEnzyme GeneEnzymesEpidemiologyEthanolEthyl AlcoholEuglycemic ClampingEuglycemic-hyperinsulinemic ClampExperimental ModelsFatsFatty LiverFatty acid glycerol estersFibrosisFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGEM modelGEMM modelGRO-seqGROseqGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneticGenetic TranscriptionGenetically Engineered MouseGlucose ClampGlucose IntoleranceGoalsGrain AlcoholGrantHepaticHepatic CellsHepatic DisorderHepatic Parenchymal CellHepatic TransplantationHepatocyteHepatologyHomeostasisHumanHyperinsulinemic ClampImpairmentIn VitroInsulin ResistanceIntracellular Communication and SignalingInvestigationInvestigatorsKO miceKineticsKnock-out MiceKnockout MiceLesionLipaseLipidsLiverLiver CellsLiver GraftingLiver SteatosisLiver TransplantLiver diseasesLong-term cohortLongitudinal cohortLoxP-flanked alleleMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMediatingMetabolicMetabolic PathwayMethylcarbinolMiceMice MammalsModel SystemModelingModern ManMolecularMurineMusNull CellsNull LymphocytesNull MouseOrigin of LifePathway interactionsPatientsPhysiologicPhysiologicalPhysiological HomeostasisPhysiologyPreventionProtein BiosynthesisProteinsRNA ExpressionRNA SeqRNA sequencingRNAseqRecurrenceRecurrentRecurrent diseaseRegulationRelapsed DiseaseResearchResearch PersonnelResearchersRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRoleSerodiagnosesSerological DiagnosisSerumSignal TransductionSignal Transduction SystemsSignalingSphingolipidsSteatohepatitisTestingTherapeuticTissuesTracerTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTranslatingTransplant RecipientsTransplantationTriacylglycerolTriacylglycerol HydrolaseTriacylglycerol LipaseTriacylglycerol acylhydrolaseTributyrinaseTriglyceridaseTriglyceride LipaseTriglyceridesTriolean HydrolaseUnited StatesUpregulationWeight GainWeight IncreaseWorkalcohol effectalcohol induced hepatic injuryalcohol induced liver disorderalcohol induced liver injuryalcohol related liver diseasealcohol-associated liver diseasealcohol-induced hepatic dysfunctionalcohol-induced liver diseasealcohol-induced liver dysfunctionalcohol-mediated liver dysfunctionalcohol-mediated liver injuryalcohol-related liver diseasealcoholic liver injurybio-markersbiologic markerbiological signal transductionbiomarkerblood glucose regulationbody weight gainbody weight increaseceramide synthasecirrhoticdevelopmentaldiagnostic biomarkerdiagnostic markerdiagnostic serologydietsdihydroceramide desaturasedisease controldisorder controlearly biomarkersearly detectionearly detection biomarkersearly detection markerseat lessepidemiologicepidemiologicalethanol effectethanol induced hepatic injuryethanol induced liver disorderethanol induced liver injuryethanol liver diseaseethanol-induced hepatic dysfunctionethanol-induced liver diseaseethanol-induced liver dysfunctionethanol-mediated liver dysfunctionethanol-mediated liver injuryflow cytophotometryfloxedfloxed allelegenetically engineered mouse modelgenetically engineered murine modelglobal run on sequencingglobal run on transcription sequencingglucose controlglucose disposalglucose homeostasisglucose regulationglucose tolerancehepatic body systemhepatic diseasehepatic gluconeogenesishepatic organ systemhepatic steatosishepatopathyhepatosteatosisimprovedin vivoin vivo Modelinsulin resistantinsulin sensitivityinsulin signalinginsulin stimulated glucose disposalinsulin tolerancelipidomicsliver disorderliver transplantationmetabolic phenotypemetabotypenovelpathwayperilipinpharmacologicpost-transplantpost-transplant diseasepost-transplantationposttransplantposttransplantationpreventpreventingproblem drinkerprotein synthesisrecidivismreduced eatingreduced food intakeskillssocial rolesynthetic enzymetherapeutic biomarkertherapeutic markertranscription factortranscriptome sequencingtranscriptomic sequencingtransplanttransplant patienttributyrasewt gain
Description preview
PROJECT SUMMARY
This proposal outlines a plan to investigate the role of ceramide synthase 6 in alcohol-induced lipid droplet
biogenesis and as a potential diagnostic biomarker of pre- and post-liver transplant alcoholic liver disease (ALD)
recurrence. The research will use novel in vitro and in vivo model systems to investigate the hypothesis…
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