grant
Molecular mechanisms of photoreceptor disc morphogenesis
NIHUS FederalResearch GrantFY2026ActinsAddressAdverse effectsBehaviorBiologyBiophysicsCausalityCell BodyCell LocomotionCell MigrationCell MovementCell membraneCellsCellular MatrixCellular MigrationCellular MotilityCellular biologyCiliaComplexCyclicityCytoplasmic MembraneCytoskeletal SystemCytoskeletonDefectDephosphorylationDysfunctionElectron MicroscopyEtiologyFluorescence Light MicroscopyFluorescence MicroscopyFrequenciesFrogFunctional ImagingFunctional disorderFutureGMO AnimalsGTP PhosphohydrolasesGTPasesGenesGenetically Modified AnimalsGoalsGuanosine Triphosphate PhosphohydrolasesGuanosinetriphosphatasesHealthImageImpairmentInositide PhospholipidsInositol PhosphoglyceridesInositol PhospholipidsIntermediary MetabolismKinasesKnock-outKnockoutLaboratoriesLightLight Signal TransductionMaintenanceMammaliaMammalsMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMembraneMetabolic ProcessesMetabolismMethodologyMiceMice MammalsModelingMolecularMonomeric G-ProteinsMonomeric GTP-Binding ProteinsMorphogenesisMurineMusOrganellesOuter pigmented layer of retinaPI(3,4,5)P3PerformancePeriodicalsPeriodicityPhosphatasesPhosphatidyl InositolPhosphatidylinositolsPhosphohydrolasesPhosphoinositidesPhosphomonoesterasesPhosphoric Monoester HydrolasesPhosphotransferase GenePhosphotransferasesPhotoradiationPhotoreceptor CellPhotoreceptorsPhotosensitive CellPhototransductionPhysiologic ImagingPhysiopathologyPigment cell layer of retinaPigmented layer of retinaPlasma MembranePolymersPositionPositioning AttributeProcessProtein DephosphorylationProteinsPtdInsRanaRegulationResearchRetinal Pigment EpitheliumRetinal pigment epithelial cellsRhythmicityRods and ConesRoleScar1 proteinSightSignal PathwaySiteSmall G-ProteinsSmall GTPasesStructureStructure of retinal pigment epitheliumSurfaceTherapeutic InterventionTimeTransgenic MiceTransgenic OrganismsTransphosphorylasesVertebrate PhotoreceptorsVisionVisual ReceptorVisual TransductionWASF1WAVE proteinWAVE1 proteinWiskott Aldrich Syndrome protein family verprolin homologWorkXenopusXenopus sp.basebasesbiophysical foundationbiophysical principlesbiophysical sciencescausationcell biologycell motilitycell typeclawed frogdepolymerizationdisease causationdisease preventiondisorder preventionexperimentexperimental researchexperimental studyexperimentsexposure to lightexposure to visible lightfascinateguanosinetriphosphataseimaginginherited retinal degenerationintervention therapyintracellular skeletonlight adverse effectlight exposurelight microscopylight pollution exposuremember 1 WAS protein familymembrane structuremorphogenetic processpathophysiologyperiodicperiodicalphosphoinositide-3,4,5-triphosphatephotoreceptor cell outer segmentphotoreceptor degenerationphotoreceptor discphysiological imagingplasmalemmapolymerpolymericpolymerizationprogramsprotein complexrecruitsensorsocial roletransgenicvisual functionvisual phototransduction
Description preview
This proposal addresses one of the most fundamental unsolved problems in vision: the molecular and cellular
mechanism responsible for building and maintaining the light-sensitive organelle of vertebrate photoreceptor cells,
the outer segment. The outer segment is a ciliary structure filled with a stack of disc membranes, which provide
vast…
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