grant
Molecular mechanisms of memory formation and tolerance in CRISPR-Cas systems
Organization SLOAN-KETTERING INST CAN RESEARCHLocation NEW YORK, UNITED STATESPosted 1 Sept 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2025Adaptive Immune SystemAffectArchaeaArchaebacteriaArchaeobacteriaArchaeonAutoimmune StatusAutoimmunityBacteriaBacterial GenomeBacteriophagesBiochemicalBiochemistryBioinformaticsBiological ChemistryBiologyBiophysicsCRISPRCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas systemCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell BodyCellsCharacteristicsClassificationClustered Regularly Interspaced Short Palindromic RepeatsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCommunicationComplexDNADNA Damage RepairDNA Molecular BiologyDNA RepairDNA SequenceDNA-Dependent RNA PolymerasesDNA-Directed RNA PolymeraseDataDeoxyribonucleic AcidDevelopmentDouble-Stranded DNAElementsEngineeringEnvironmentGene TranscriptionGenesGeneticGenetic TranscriptionGenomeGenomicsGoalsHealthHost FactorHost Factor ProteinHumanImmune memoryImmune responseImmune systemImmunityImmunologic MemoryImmunological MemoryImpairmentInfectionIntegraseIntegration Host FactorsInvadedLaboratoriesLinkLocationMediatingMemoryMentorshipMobile Genetic ElementsModern ManMolecularMolecular BiologyNon-Polyadenylated RNANucleic AcidsOutcomePathogenicityPhagesPhysiologicPhysiologicalPlasmidsPopulationProcessRNARNA ExpressionRNA Gene ProductsRNA PolymerasesResearchResearch DesignRibonucleic AcidRibosomal RNARoleS epidermidisS. epidermidisSiteStaphylococcus epidermidisStudy TypeSystemSystematicsTestingTranscriptTranscriptionTransfer RNATriplet Codon-Amino Acid AdaptorUniversitiesUnscheduled DNA SynthesisWorkWritingacquired immune systemanamnestic reactionbacterial virusbiological systemsbiophysical foundationbiophysical principlesbiophysical sciencescareercold shock proteincostdevelopmentalds-DNAdsDNAexperimentexperimental researchexperimental studyexperimentsfitnessgenome editinggenome wide screengenomic editinggenotoxicityhost responseimmune system responseimmunoresponseimprovedinfection recurrenceinsightmemory acquisitionmolecular diagnosticsnucleasepreventpreventingpromoterpromotorrRNArecruitrecurrent infectionrecurring infectionsecondary immune responseskillssocial rolestudy designtRNAtech developmenttechnology developmenttooltransfer Ribonucleic acids
Description preview
Project Summary
CRISPR-Cas are prokaryotic adaptive immune systems that protect bacteria and archaea from invading mobile
genetic elements, such as phages and plasmids. CRISPR-Cas systems acquire immunological memories during
infection by integrating short fragments from the invader’s genome into the CRISPR locus of the host. These
fragments,…
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