grant
Molecular mechanisms of force production and force sensing during clathrin-mediated endocytosis
NIHUS FederalResearch GrantFY2026ActinsBindingBiochemistryBiologic ModelsBiological ChemistryBiological FunctionBiological ModelsBiological ProcessBiomechanicsCancersCapsid ProteinsCell BodyCell FunctionCell LocomotionCell MigrationCell MovementCell PhysiologyCell ProcessCell divisionCell membraneCellsCellular FunctionCellular MatrixCellular MigrationCellular MotilityCellular PhysiologyCellular ProcessCensusesClathrinCoat ProteinsColorColoring AgentsCommunicable DiseasesCommunicationCommunitiesCore ProteinCytoplasmic MembraneCytoskeletal SystemCytoskeletonDefectDiameterDiseaseDisorderDyesEndocytosisEnvironmentEukaryotaEukaryoteEukaryotic CellEvolutionFission YeastFoundationsHealthImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionIndividualInfectious DiseasesInfectious DisorderLipid BindingLipidsMalignant NeoplasmsMalignant TumorMath ModelsMeasurementMeasuresMechanicsMediatingMembraneMetabolic syndromeMethodologyMicroscopyModel SystemModelingMolecularMolecular InteractionMovementMyosin IMyosin Type INamesNeuropathyNutrientOrganismPlasma MembranePolymersPositionPositioning AttributeProcessProductionProteinsQuantitative MicroscopyReceptor ProteinRecyclingRegulationRoleS pombeS. pombeSchizosaccharomyces pombeShapesStructureSubcellular ProcessSurfaceSystemTestingTransmissionVesicleViral Coat ProteinsViral Outer Coat ProteinVirusYeastsbasebasesbiomechanicalbody movementcell motilitycoated pitdevelopmental diseasedevelopmental disorderflexibilityflexibleforce sensorgene manipulationgenetic manipulationgenetically manipulategenetically perturbgenome editinggenomic editingin silicoin vivointerdisciplinary approachintracellular skeletonlipid boundliving systemmalignancymathematic modelmathematical modelmathematical modelingmechanicmechanicalmechanical forcemembrane structuremolecular scalemulti-scale computational modelingmulti-scale mathematical modelingmulti-scale modelingmultidisciplinary approachmultiscale computational modelingmultiscale mathematical modelingmultiscale modelingnamenamednamingneoplasm/cancerneuropathicnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathogenplasmalemmapolymerpolymericpolymerizationpressureprogenitor cell differentiationprogenitor differentiationreceptorsingle moleculesocial rolestem and progenitor differentiationstem cell differentiationtooltransmission processvirtual
Description preview
ABSTRACT
Mechanical forces are central to a broad range of molecular and cellular biological processes in health
(e.g. cell motility, cell division, endocytosis, stem cell differentiation, etc.) and disease (e.g. cancer,
immunological disorders, developmental disorder, infectious diseases, etc.). However, our understanding of
forces within cells…
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