grant
Molecular mechanisms of Eph receptor signaling
Organization OHIO STATE UNIVERSITYLocation Columbus, UNITED STATESPosted 15 Jul 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025BiochemicalBiologic ModelsBiological FunctionBiological ModelsBiological ProcessBiologyBiophysicsBody TissuesCancersCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell SignalingCell to Cell Communication and SignalingCell-Cell SignalingCell-to-Cell InteractionCellsCommunicationDevelopmentDiseaseDisorderDissectionEmbryo DevelopmentEmbryogenesisEmbryonic DevelopmentEnsureEnzymatic BiochemistryEnzymologyEph Family ReceptorsEph Receptor Tyrosine KinaseEph ReceptorsEphrin ReceptorsEventEvolutionFamilyFamily memberHealthHigh-Throughput Nucleotide SequencingHigh-Throughput SequencingHomoHumanIn VitroIndividualIntracellular Communication and SignalingLightLinkMalignant NeoplasmsMalignant TumorMembraneMicroscopyModel SystemModern ManMolecularNatureNerve DegenerationNeuron DegenerationOpticsOrganismOrganoidsOutcomePTK ReceptorsPatternPhotoradiationReceptor ActivationReceptor ProteinReceptor Protein-Tyrosine KinasesReceptor SignalingReceptor Tyrosine Kinase GeneRegulationResearchRoleSideSignal TransductionSignal Transduction SystemsSignalingTissuesTransmembrane Receptor Protein Tyrosine KinaseTyrosine Kinase Linked ReceptorsTyrosine Kinase ReceptorsWorkbiological signal transductionbiophysical foundationbiophysical principlesbiophysical sciencesdevelopmentalerythropoietin-producing human hepatoma receptorexperimentexperimental researchexperimental studyexperimentsfluorescence imagingfluorescent imaginggenome editinggenomic editingintercellular communicationinterestliving systemmalignancymembrane structureneoplasm/cancerneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronal degenerationopticaloptogeneticsprogramsprotein oligomerreceptorresponsesingle moleculesocial rolestoichiometrytool
Description preview
PROJECT SUMMARY
The survival of every multicellular organism relies on effective cell-cell communication. Despite the diversity of
signals that cells need to communicate to their neighbors, evolution appears to have settled on only a few
physical mechanisms for transferring information across membranes. One such mechanism is the
oligomerization,…
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