grant
Molecular mechanisms of enterovirus D68 viral entry mediated by the MFSD6 receptor
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY20250-11 years oldAcute PoliomyelitisAmino AcidsAnti-viral AgentsAssayAttentionBindingBioassayBiological AssayBody TissuesBrain regionCNS Nervous SystemCNS infectionCRISPRCRISPR editing screenCRISPR screenCRISPR-based screenCRISPR/Cas systemCRISPR/Cas9 screenCapsidCell BodyCell LineCell membraneCellLineCellsCellular MembraneCentral Nervous SystemCentral Nervous System InfectionsCentral Nervous System Infectious DiseaseCentral Nervous System Infectious DisorderCessation of lifeChildChild YouthChildren (0-21)ClinicalClustered Regularly Interspaced Short Palindromic RepeatsCollaborationsCryo-electron MicroscopyCryo-electron tomographyCryoelectron MicroscopyCytoplasmic MembraneCytosolDataDeathDevelopmentDiseaseDisease OutbreaksDisorderEV-68EV-D68Electron CryomicroscopyEngineeringEnterovirusEnterovirus 68Enterovirus D68Enterovirus InfectionsEpidemicEpithelial CellsFamily PicornaviridaeFutureGeneticGenomeGoalsHospital AdmissionHospitalizationHost FactorHost Factor ProteinHumanHuman Cell LineHuman poliovirusICAM-5ImageImmune responseIn SituIn VitroInduced pluripotent stem cell derived neuronsInfectionInfection preventionIntegration Host FactorsInvestigatorsKnock-outKnockoutLaboratoriesLicensingLungLung Respiratory SystemMapsMediatingMedulla SpinalisMembrane Transport ProteinsMembrane TransportersMiceMice MammalsModelingModern ManMolecularMolecular InteractionMolecular VirologyMurineMusMuscleMuscle TissueN-Acetylneuraminic AcidsNeuraxisNeuron from iPSCNeuron from induced pluripotent stem cellsNeuropathogenesisNon-Polyadenylated RNAOutbreaksPalsyParalysedPathogenesisPatternPenetrationPicornaviridaePicornavirusesPlasma MembranePlegiaPolioPolio VirusPoliomyelitisPoliovirusPrevent infectionProductivityProteinsRNARNA Gene ProductsReceptor ProteinResearch PersonnelResearchersResolutionRespiratory DiseaseRespiratory EpitheliumRespiratory Signs and SymptomsRespiratory System DiseaseRespiratory System DisorderRibonucleic AcidRoleSialic AcidsSpinal CordStrains Cell LinesStructureStructure of respiratory epitheliumSymptomsSyndromeTM DomainTelencephalonTestingTherapeuticTissuesTransmembrane DomainTransmembrane RegionVaccinationVaccinesVariantVariationViralViral DiseasesViral ReceptorVirionVirusVirus DiseasesVirus ParticleVirus Receptorsaccess to vaccinationaccess to vaccinesacute flaccid myelitisairway epitheliumairway symptomaminoacidanti-viral compoundanti-viral drugsanti-viral medicationanti-viral therapeuticanti-viralscellular targetingclinical relevanceclinically relevantclustered regularly interspaced short palindromic repeats screenconditional knock-outconditional knockoutcryo-EMcryo-EM tomographycryoEMcryoEM tomographycryoelectron tomographycryogenic electron microscopycultured cell linedevelopmentalelectron cryo-tomographyelectron tomographyextracellulargastrointestinal symptomgenome scalegenome-widegenomewidehost responseiPS neuronsiPSC derived-neuronsimagingimmune system responseimmunoresponsein vivoinduced pluripotent stem cell neuronsinsightkidsmouse modelmurine modelmuscularneurons derived from induced pluripotent stem cellsneurons differentiated from induced pluripotent stem cellsneurotropicpandemic concernpandemic potentialpandemic riskpandemic threatparalysisparalyticparticlepathogenplasmalemmapoliomyelitis viruspreventpreventingreceptorresolutionsrespiratory symptomrespiratory tract epitheliumrespiratory virussmall moleculesocial rolestructural biologytelencephalintherapeutic evaluationtherapeutic testingvaccination accessvaccination availabilityvaccine accessvaccine availabilityviral RNAviral infectionvirologyvirus RNAvirus host interactionvirus infectionvirus-induced diseaseyoungster
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PROJECT SUMMARY
Nonpolio enteroviruses are ubiquitous viruses that generally cause mild respiratory and gastrointestinal
symptoms but can, in rare cases, cause severe disease. Recent outbreaks of enterovirus D68 (EV-D68) have
been associated with severe respiratory disease requiring hospitalization and neuropathogenesis, including
polio-like…
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