grant
Molecular mechanisms of endocytic initiation and cargo selection
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 20 Sept 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AP2AP2 ProteinAP2TF ProteinActivator Protein 2AddressAreaAutomobile DrivingBindingBiochemicalCancersCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCell SurvivalCell ViabilityCell membraneCellular FunctionCellular PhysiologyCellular ProcessClathrinClathrin AdaptorsClathrin Assembly ProteinsClathrin-Associated AdaptorsClathrin-Associated ProteinsCoated vesicleComplexCryo-electron MicroscopyCryoelectron MicroscopyCuesCytoplasmic MembraneDNA mutationDataDecision MakingDefectDevelopmentDiseaseDisorderElectron CryomicroscopyEndocytosisEnvironmentFluorescence Light MicroscopyFluorescence MicroscopyG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsGPCRGenetic ChangeGenetic defectGenetic mutationGrowth AgentsGrowth FactorGrowth SubstancesIntracellular Communication and SignalingLeadMalignant NeoplasmsMalignant TumorMediatingMedicalMembraneMethodologyModelingMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMutationNatureNerve DegenerationNeuron DegenerationNormal CellNutrientPb elementPhosphorylationPlasma MembraneProcessProtein FamilyProtein PhosphorylationProteinsProteins Growth FactorsQuality ControlRegulationResearchRoleRouteSignal TransductionSignal Transduction SystemsSignalingSortingSubcellular ProcessSystems DevelopmentTFAP2 ProteinVesicleactivator protein AP-2biological signal transductionconformationconformationalconformational stateconformationallyconformationscryo-EMcryoEMcryogenic electron microscopydevelopmentaldisease modeldisorder modeldrivingdrug developmentenhancer-binding protein AP-2experimentexperimental researchexperimental studyexperimentsextracellulargenome mutationheavy metal Pbheavy metal leadhuman diseaseinsightinterdisciplinary approachlive cell imagelive cell imaginglive cellular imagelive cellular imagingmalignancymembrane structuremultidisciplinary approachneoplasm/cancerneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronal degenerationplasmalemmareconstitutereconstitutionresponsesingle moleculesocial rolespatial and temporalspatial temporalspatiotemporaltranscription factor AP-2transcription factor AP2uptake
Description preview
Abstract
The primary route of internalization from the plasma membrane is clathrin-mediated endocytosis (CME), which
is required for vital cellular processes such as signaling, nutrient uptake, and development. While the molecular
mechanisms underlying the late stages of vesicle formation are well studied, the mechanisms underpinning the
earliest…
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