grant
Molecular Mechanisms of Cell Cycle Control
Organization UNIV OF MASSACHUSETTS MED SCH WORCESTERLocation WORCESTER, UNITED STATESPosted 1 May 2020Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025Basal Transcription FactorBasal transcription factor genesBudding YeastCancersCell BodyCell CycleCell Cycle ArrestCell Cycle ControlCell Cycle ProgressionCell Cycle RegulationCell Division CycleCell divisionCellsCellular ExpansionCellular GrowthChronic stressCyclin-Dependent KinasesCyclin-Dependent Protein KinasesDNA mutationDevelopmentDiseaseDisorderEndomycetalesEnsureEnvironmentExposure toGeneral Transcription Factor GeneGeneral Transcription FactorsGenetic ChangeGenetic defectGenetic mutationGoalsHumanHuman ActivitiesIndividualInterventionLaboratoriesMalignant CellMalignant NeoplasmsMalignant TumorModern ManMolecularMutationPathway interactionsPhosphorylationPhosphorylation SiteProliferatingProtein PhosphorylationProteinsRegulationSaccharomycetalesSiteStressSystemTranscription Factor Proto-OncogeneTranscription factor genesbiological adaptation to stresscancer cellcdk Proteinscell growthdevelopmentalgenome mutationinsightmalignancyneoplasm/cancerpathwaypreventpreventingprotein functionreaction; crisisresistance to therapyresistant to therapystress responsestress; reactionstressortherapeutic resistancetherapy resistanttranscription factortreatment resistance
Description preview
ABSTRACT
Regulated progression through the cell cycle is essential for normal development and to prevent uncontrolled
proliferation that can lead to cancer. The focus of my laboratory is to understand the molecular mechanisms that
control cell growth and division, with the goal of understanding how mutations in the cell cycle-regulatory network…
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