grant
Molecular mechanisms of alkane hydroxylase (AlkB) reactivity and selectivity
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DActive SitesAlcohol Chemical ClassAlcoholsAlkane 1-HydroxylaseAlkane 1-monooxygenaseAlkane HydroxylaseAlkanesArchaeaArchaebacteriaArchaeobacteriaArchaeonAttention Deficit DisorderBacteriaBindingBiochemicalCYP4ACYP4A11CYP4A11 geneCYP4AIICancersCarbonChemistryChimera ProteinChimeric ProteinsCryo-electron MicroscopyCryoelectron MicroscopyCytochrome P-450 4ACytochrome P-450 CYP4ACytochrome P-450 IVACytochrome P450, Subfamily IVA, Polypeptide 11Diabetes MellitusElectron CryomicroscopyElectron TransportElectronsEnvironmentEnvironmental HealthEnvironmental Health ScienceEnzyme GeneEnzymesFamilyFatty Acid Omega-HydroxylaseFatty AcidsFe elementFusion ProteinFutureHistidineHumanHydroxylasesHydroxylationIntegral Membrane ProteinIntermediary MetabolismIntrinsic Membrane ProteinIonsIronKnowledgeLaurate Omega-HydroxylaseLauric Acid HydroxylaseLauric Acid MonooxygenaseLauric Acid Omega-hydroxylaseLibrariesLifeLinkLipidsMalignant NeoplasmsMalignant TumorMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMetabolic ProcessesMetabolismMixed Function OxidasesMixed Function OxygenasesModalityModern ManMolecularMolecular InteractionMonooxygenasesMyelin SheathNegative Beta ParticleNegatronsNerve DegenerationNeuron DegenerationObesityOilsOmega-1 HydroxylaseOmega-HydroxylaseOmega-Lauryl HydroxylaseOxidation-ReductionPatternProductionProtein FamilyProteinsPublishingReactionRedoxReportingSphingolipidsStructureSurface ProteinsTechniquesTherapeuticTransmembrane ProteinTransmembrane Protein GeneVariantVariationWorkadipositycorpulencecryo-EMcryoEMcryogenic electron microscopydiabeteselectron transferelectronic structureinsightmalignancymembermetalloenzymemutation scanningmutation screeningneoplasm/cancerneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronal degenerationoxidation reduction reactionprogramsstructural determinantsstructural factorstherapeutic targetthree dimensional
Description preview
Abstract
The class-III diiron proteins, a group of integral membrane proteins unified by a histidine-rich
active site, catalyze a wide range of reactions including hydroxylations required for the production
of sphingolipids (an essential component of the myelin sheath), desaturating fatty acids that
regulate metabolism and cancer progress, and…
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