grant
Molecular mechanisms controlling tooth development
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 1 Sept 2024Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AffectBacterial InfectionsBasal Transcription FactorBasal transcription factor genesBasic Mechanisms of SUMOylationBody TissuesCariesCell BodyCell CycleCell Cycle ControlCell Cycle ProgressionCell Cycle RegulationCell DifferentiationCell Differentiation processCell Division CycleCell Growth in NumberCell LineCell MultiplicationCell ProliferationCell TherapyCellLineCellsCellular ProliferationCenters for Disease ControlCenters for Disease Control and PreventionCenters for Disease Control and Prevention (U.S.)ChromatinCommunicable DiseasesDataDentalDental DecayDental EnamelDental cariesDentinDentinogenesisDentinogenesis ImperfectaDentistryDevelopmentDifferentiation in cell cultureDirect CostsEmbryoEmbryonicEnamelEnhancersEpitheliumEstheticsExpression SignatureFractureFutureGene Expression ProfileGeneral PopulationGeneral PublicGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic DiseasesGoalsHomeobox 7.1 ProteinIn VitroIn vitro cell differentiationInfectious DiseasesInfectious DisorderInjuryKnowledgeLeadMSX1 Transcription FactorMesenchymalMesenchymal DifferentiationMesenchymal Progenitor CellMesenchymal Stem CellsMesenchymal progenitorMesenchymal stromal/stem cellsMesenchymasMesenchymeMethodsMolecularMolecular FingerprintingMolecular ProfilingMsh Homeo Box Homolog 1 ProteinMultipotent Stem CellsMutant Strains MiceNatural regenerationOdontoblastsOdontogenesisOrganOrganogenesisPathway interactionsPatientsPb elementPlayPopulationPrevalenceProcessProgenitor CellsProliferatingProteinsPublic HealthRegenerating teethRegenerating toothRegenerationRepressionResearch DesignRoleSUMOylationSeriesSnailsSourceStrains Cell LinesStudy TypeSumoylation PathwayTeeth regenerationTestingTherapeuticTissuesToothTooth DiseasesTooth DisorderTooth regenerationTooth structureTranscription Factor Proto-OncogeneTranscription factor genesUnited States Centers for Disease ControlUnited States Centers for Disease Control and PreventionWorkbacteria infectionbacterial diseasebone fracturecell based interventioncell mediated interventioncell mediated therapiescell typecell-based therapeuticcell-based therapycellular differentiationcellular therapeuticcellular therapycostcultured cell linedental developmentdental diseasedental disorderdevelopmentaldifferentiation in culturedifferentiation in vitrofunctional restorationgene expression patterngene expression signaturegene signaturesgenetic conditiongenetic disordergenetic signaturehealingheavy metal Pbheavy metal leadin vitro cellular differentiationinhibitorinjuriesmesenchymal stromal cellmesenchymal stromal progenitor cellsmesenchymal-derived stem cellsmolecular profilemolecular signaturemouse mutantmultipotent progenitormultipotent progenitor cellmutantpathwayprogenitor cell based therapyprogenitor cell differentiationprogenitor cell poolprogenitor cell populationprogenitor cell proliferationprogenitor cell therapyprogenitor cell treatmentprogenitor differentiationprogenitor poolprogenitor populationprogenitor proliferationprogenitor therapyprogenitor treatmentprotein protein interactionregenerateregenerativerestore functionrestore functionalityrestore lost functionscATAC sequencingscATAC-seqscRNA sequencingscRNA-seqsingle cell ATAC-seqsingle cell ATAC-sequencingsingle cell Assay for Transposase Accessible Chromatin sequencingsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell sequencing assay for transposase accessible chromatinsingle cell transcriptomic profilingsingle-cell Assay for Transposase-Accessible Chromatin with sequencingsingle-cell RNA sequencingsingle-cell assay for transposase-accessible chromatin using sequencingsingle-cell assay for transposase-accessible chromatin-seqsocial rolestem and progenitor cell populationstem and progenitor cell proliferationstem and progenitor cell therapystem and progenitor differentiationstem cell based therapystem cell differentiationstem cell mediated therapystem cell poolstem cell populationstem cell proliferationstem cell therapeuticsstem cell therapystem cell treatmentstem cell-based therapeuticstem cell-based treatmentstem cellsstudy designteethtooth decaytooth enameltranscription factortranscriptional profiletranscriptional signature
Description preview
PROJECT SUMMARY
Genetic diseases such as tooth agenesis, dentinogenesis imperfecta, infectious diseases such as caries or
fractures represent common public health problems that affect up to 30-40% of the population worldwide and
impose significant burdens on patients (Centers for Diseases Control and Prevention, 2019). The estimated
direct costs…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click