grant
Molecular Mechanisms and Evolution of the Rhoptry Secretion System
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Jun 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2026ApicalArchitectureBiological FunctionBiological ProcessCryo-electron MicroscopyCryo-electron tomographyCryoelectron MicroscopyElectron CryomicroscopyEngineering / ArchitectureEukaryotaEukaryoteEventEvolutionFreezingGeneticImageInvadedInvestigationKnowledgeMacromolecular StructureMethodsMicroscopyModelingMolecularMolecular EvolutionMolecular StructureMolecular and Cellular BiologyOrganellesOrganismParasitesPlasmodiumProcessProteomicsResearchResearch Project SummariesSamplingStructureSystemT gondiiT. gondiiTechnologyTetrahymena thermophilaTimeToxoplasmaToxoplasma gondiiVariantVariationVesiclecryo-EMcryo-EM tomographycryoEMcryoEM tomographycryoelectron tomographycryogenic electron microscopyelectron cryo-tomographyimaginginnovateinnovationinnovativeinsightinterdisciplinary approachliving systemmicrobialmolecular assemblymolecular assembly/self assemblymolecular self assemblymultidisciplinary approachnovelprogramsrhoptryspatial and temporalspatial temporalspatiotemporalstructural biology
Description preview
PROJECT SUMMARY
This research program focuses on understanding the rhoptry secretion system in unicellular eukaryotes within
the Alveolata superphylum, including apicomplexan parasites and non-pathogenic ciliates. Apicomplexans,
such as Toxoplasma and Plasmodium, utilize rhoptry secretion for host invasion, a process with poorly
understood…
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