grant
Molecular mechanism of Zika virus-induced premature craniofacial suture closure
Organization CLEVELAND CLINIC LERNER COM-CWRULocation CLEVELAND, UNITED STATESPosted 1 Jan 2024Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY20250-11 years oldAblationAddressAffectAfricanAmericasAnatomic AbnormalityAnatomical AbnormalityAsianBackBasic ResearchBasic ScienceBirthBirth DefectsBody TissuesBone DiseasesBrainBrain Nervous SystemCalcifiedCalvariaCausalityCell BodyCellsCephalicChildChild YouthChildhoodChildren (0-21)ClinicalCongenital AbnormalityCongenital Anatomical AbnormalityCongenital DefectsCongenital DeformityCongenital MalformationCranialCranial SuturesCraniofacial AbnormalitiesCraniosynostosisDataDefectDeformityDepositDepositionDevelopmental DelayDevelopmental Delay DisordersDifferentiated GeneDisease OutbreaksDorsumDown-RegulationEarly InterventionEmbryoEmbryonicEncephalonEngineeringEtiologyExpression LibraryFetusFutureGLI Family GeneGLI Family ProteinGLI ProteinGLI geneGLI1GLI1 GeneGLI1 ProteinGene ExpressionGeneticGestationGlioma Associated Oncogene Homolog 1 ProteinGlioma Associated Oncogene Homolog ProteinGlioma-Associated Oncogene HomologGlioma-associated oncogeneGoalsHealthHumanImmunocompetentIn VitroIndividualInfantInfectionJoint structure of suture of skullKI miceKnock-in MouseLacZLacZ GenesLentiviral VectorLentivirus VectorLineage TracingLinkMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMesenchymalMesenchymal Progenitor CellMesenchymal Stem CellsMesenchymal progenitorMesenchymal stromal/stem cellsMesenchymasMesenchymeMiceMice MammalsMicrocephalyModelingModern ManMolecularMothersMurineMusNeural DevelopmentNeurologicNeurologicalOutbreaksParturitionPathway interactionsPatternPeptidesPhenotypePopulationPregnancyProcessProgenitor CellsProteinsRNA SeqRNA sequencingRNAseqReportingResolutionRiskRoleSideSiteSkullSpecific Child Development DisordersSurgical suturesSuturesTechnologyTestingTherapeutic InterventionTissuesTransmissionVertical TransmissionViralViral GenesVirusZIKVZIKV exposureZIKV infectedZIKV infectionZIKV positiveZika VirusZika exposureZika virus exposureZika virus infectionaptamerbonebone disordercalcificationcalcium phosphatecalvarialcausationcell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcell typecellular lineage mappingcellular lineage trackingcohortcraniofacialcraniofacial anomaliescraniofacial bonecraniofacial defectscraniofacial malformationcraniofaciescraniumdisease causationearly childhoodepidemic virusexposure to ZIKVexposure to Zikaexposure to Zika virusfetalfetal infectionfuture pandemicglioma associated oncogene 1glioma associated oncogene family zinc finger 1global gene expressionglobal healthglobal transcription profileimmune competentin vivoinfant infectioninfected infantinfected with ZIKVinfected with zikainnovateinnovationinnovativeinsightintervention therapykidsknockin micemesenchymal stromal cellmesenchymal stromal progenitor cellsmesenchymal-derived stem cellsmicrencephalymicroencephalymineralizationmouse modelmurine modelmutantneuro-sensoryneurodevelopmentneurosensorynext pandemicnovelosteoblast progenitorosteoblast stem cellosteogenicosteogenic progenitorosteogenic stem cellosteoprogenitorosteoprogenitor cellpathwaypediatricpre-clinicalpreclinicalprematureprematurityprenatalprospectiveprotein purificationpupresolutionsscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestem cellssuccesssuture fusiontherapeutic agent developmenttherapeutic developmenttranscriptometranscriptome sequencingtranscriptomic sequencingtranscriptomicstransmission processunbornviral testingviral transmissionvirus testingvirus transmissionyoungsterzika infectedzika infectionzika viral infectionzikav
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Project Summary/Abstract
The 2015-2016 Zika virus (ZIKV) outbreaks in the Americas have become a major global health concern due to
their association with pre-natal birth defects such as microcephaly. Since the last outbreak, ZIKV has spilled
back to the wildlife to establish persistent reservoir populations, and this has sparked concerns of…
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