grant
Molecular Magnetic Resonance of Hepatic Fibrogenesis
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 3 Jul 2019Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2026AcuteAffinityAlcohol abuseAldehydesAmino AcidsAnimal ModelAnimal Models and Related StudiesAnimalsBindingBiochemicalBody TissuesCausalityCell Communication and SignalingCell SignalingChemopreventionChemopreventiveChemopreventive AgentCholine DeficiencyChronicCicatrixClinicalCollagenCollagen Type ICommon Rat StrainsDENADevelopmentDiabetes MellitusDiethylnitrosamineDiseaseDisease ProgressionDisorderDoseDrug abuseEarly DiagnosisErlotinibEtOH abuseEtiologyFibrosisFundingGoalsGrantHCVHemi-MyeloperoxidaseHepatic CancerHepatic DisorderHepatic FibrogenesisHepatitis C virusHepatocarcinomaHepatocellular CarcinomaHepatocellular cancerHepatomaHigh Fat DietHistologicHistologicallyHistopathologyImageInflammationInjectionsIntracellular Communication and SignalingKineticsLibrariesLiverLiver Cells CarcinomaLiver FibrosisLiver diseasesMR ImagingMR TomographyMRIMRIsMagnetic ResonanceMagnetic Resonance ImagingMalignant neoplasm of liverMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMetabolic DiseasesMetabolic DisorderMethodsMiceMice MammalsModelingMolecularMolecular DiseaseMolecular InteractionMolecular ProbesMurineMusMyeloperoxidaseN,N-diethylnitrosamineN-NitrosodiethylamineN-diethylnitrosamineN-ethyl-N-nitroso-ethanamineNASHNDEANMR ImagingNMR TomographyNitrosodiethylamineNuclear Magnetic Resonance ImagingPathway interactionsPatientsPeptidesPeroxidasesPre-Clinical ModelPreclinical ModelsPredicting RiskPrediction of Response to TherapyPreventative interventionPrimary Malignant Neoplasm of LiverPrimary carcinoma of the liver cellsPrimary liver cancerRatRats MammalsRattusRiskRisk ReductionRodent ModelScarsSignal TransductionSignal Transduction SystemsSignalingSiteSpecificityTarcevaTestingThesaurismosisTissuesTreatment EfficacyType 1 CollagenVirusWorkZeugmatographyabuse of drugsabuses drugsalcohol co-abusealcohol problemaminoacidanti-carcinogenicantifibrotic agentantifibrotic medicationantifibrotic therapyantifibrotic treatmentbiological signal transductioncausationchelationchemoprevention agentchronic hepatic diseasechronic hepatic disorderchronic liver diseasechronic liver disorderdetermine efficacydevelopmentaldiabetesdisease causationearly detectionefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationethanol abuseevaluate efficacyexamine efficacyfibrogenesisfibrotic liverforecasting riskhazardous alcohol usehepatic body systemhepatic diseasehepatic fibrosishepatic organ systemhepatopathyhigh risk grouphigh risk individualhigh risk peoplehigh risk populationimagingintervention efficacyintervention for preventionliver cancerliver carcinomaliver developmentliver disorderliver fibrogenesisliver malignancymalignant liver tumormetabolism disordermodel of animalmolecular imagingmolecule imagingmortalitymouse modelmurine modelnon-alcohol induced steatohepatitisnon-alcoholic steato-hepatitisnon-alcoholic steatohepatitisnonalcoholic steato-hepatitisnonalcoholic steatohepatitisnoveloutcome predictionoxidationpathwaypredict riskpredict riskspredict therapeutic responsepredict therapy responsepredicted riskpredicted riskspredicting riskspredictive riskpredicts riskpreventpreventingprevention interventionpreventional intervention strategypreventive interventionproblem alcohol useproblem drinkingproblematic alcohol consumptionproblematic alcohol useprogression riskquantitative imagingreal time monitoringrealtime monitoringreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskresponserisk predictionrisk predictionsrisk-reducingscreeningscreeningstherapeutic efficacytherapy efficacytherapy predictiontooltreatment predictiontreatment response prediction
Description preview
A. Specific Aims
Identification of high-risk populations suitable for screening and chemoprevention of hepatocellular carcinoma (HCC) has been proposed as an effective and efficient strategy to impact HCC-related mortality. Screening and earlier detection of HCC has had some impact on HCC mortality. However, the absence of tools to accurately…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click