grant
Molecular interplay of HIV Tat, cocaine, and cART in microglial pyroptosis: Role of NLRP3 inflammasome
Organization UNIVERSITY OF NEBRASKA MEDICAL CENTERLocation OMAHA, UNITED STATESPosted 15 Apr 2025Deadline 31 Jan 2030
NIHUS FederalResearch GrantFY202621+ years oldAIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAdultAdult HumanAffectAnti-Retroviral AgentsApoptosisApoptosis PathwayApoptosis-Related Cysteine Protease Caspase 1AssayAstrocytesAstrocytusAstrogliaBehaviorBeta Proprotein Interleukin 1BindingBioassayBiological AssayBody TissuesBrain regionCASP-1CASP1CASP1 geneCNS Nervous SystemCaspase-1Caspase-1 GeneCell Communication and SignalingCell DeathCell SignalingCenters for Disease ControlCenters for Disease Control and PreventionCenters for Disease Control and Prevention (U.S.)Central Nervous SystemChronicCocaineCocaine use disorderConfocal MicroscopyDataDevelopmentDiseaseDisorderDrugsELISAEnzyme-Linked Immunosorbent AssayEpidemicExposure toGene InactivationGene SilencingGenerationsGliaGlial CellsGoalsHIVHIV 1 associated neurocognitive disorderHIV InfectionsHIV associated neurocognitive deficitHIV associated neurocognitive impairmentHIV associated neurological diseaseHIV associated neurological disorderHIV individualsHIV induced neurocognitive deficitHIV induced neurocognitive impairmentHIV infected individualsHIV infected personsHIV infection persistenceHIV neurocognitive impairmentHIV peopleHIV persistenceHIV positive individualsHIV positive peopleHIV viral infectionHIV viral persistenceHIV virus infectionHIV-1HIV-1 associated neurocognitive deficitHIV-1 associated neurocognitive disorderHIV-1 associated neurocognitive impairmentHIV-1 infectionHIV-1 persistenceHIV-IHIV-associated neurocognitive disorderHIV1HandHomolog of Drosophila TOLLHortega cellHuman Immunodeficiency Virus Type 1Human Immunodeficiency Virus-1Human Immunodeficiency VirusesHuman immunodeficiency virus 1ICE ProteaseIFN-Gamma-Inducing Factor GeneIFN-gamma-Inducing FactorIGIFIGIF GeneIL-1 GammaIL-1 Gamma GeneIL-1 betaIL-1 beta ConvertaseIL-1 beta-Converting EnzymeIL-1 βIL-1-bIL-18IL-18 GeneIL-1BCIL-1b Converting EnzymeIL-1gIL-1g GeneIL-1βIL1-BetaIL1-βIL18IL18 ProteinIL18 geneIL1B ProteinIL1B-ConvertaseIL1BCIL1BCEIL1F2IL1F4IL1F4 GeneIL1βImmunoblottingIn VitroIndividualInfection by HIV-1Infection from HIV-1Infection of HIV-1InflammasomeInflammationInflammatoryInnate Immune ResponseInterferon-Gamma-Inducing Factor GeneInterferon-gamma-Inducing FactorInterleukin 1-B Converting EnzymeInterleukin 1-Beta ConvertaseInterleukin 18 (Interferon-Gamma-Inducing Factor)Interleukin 18 (Interferon-Gamma-Inducing Factor) GeneInterleukin 18 ProproteinInterleukin 18 Proprotein GeneInterleukin 1betaInterleukin-1 Beta Converting EnzymeInterleukin-1 Converting EnzymeInterleukin-1 GammaInterleukin-1 Gamma GeneInterleukin-1 betaInterleukin-18Interleukin-18 PrecursorInterleukin-18 Precursor GeneInterleukin-1βInterventionIntracellular Communication and SignalingInvestigationKnowledgeKolliker's reticulumLAV-HTLV-IIILinkLymphadenopathy-Associated VirusMGC12320MGC12320 GeneMacacaMacaqueMediatingMediatorMedicationMembraneMethodsMiceMice MammalsMicrogliaMolecularMolecular InteractionMurineMusNeuraxisNeurocognitive Impairment in HIVNeurocognitive Impairment in HIV-1NeurogliaNeuroglial CellsNeurologicNeurologicalNeuropathogenesisNon-neuronal cellNonneuronal cellPLWHPWHPathogenesisPathway interactionsPatientsPharmaceutical PreparationsPreinterleukin 1 BetaProcessProgrammed Cell DeathProteinsResearchResidualResidual stateRoleShort interfering RNASignal PathwaySignal TransductionSignal Transduction SystemsSignalingSmall Interfering RNAStaining methodStainsSubstance abuse problemTLR proteinTLR4TLR4 geneTestingTissuesToll HomologueToll-Like Receptor Family GeneToll-like receptorsTrans-Acting FactorsTrans-ActivatorsTransactivatorsTranscription ActivatorTranscription CoactivatorTranscription Factor CoactivatorTranscriptional Activator/CoactivatorTransgenic MiceUnited States Centers for Disease ControlUnited States Centers for Disease Control and PreventionValidationViral Gene ProductsViral Gene ProteinsViral ProteinsVirus-HIVWestern BlottingWestern Immunoblottingabuse of substancesadulthoodanti-retroviralantiretroviral therapyantiretroviral treatmentastrocytic gliabiological signal transductionbrain tissueco-morbidco-morbiditycombinatorialcomorbiditycytokinedevelopmentaldrug/agenteffective therapyeffective treatmentenzyme linked immunoassaygitter cellglial activationglial cell activationhandshuman immunodeficiency virus infectionhuman immunodeficiency virus persistencein vivoindividuals infected with HIVindividuals with HIVindividuals with human immunodeficiency virusinfected with HIVinfected with human immunodeficiency virusinhibitorinsightmembrane structuremesogliamicroglial cellmicrogliocytemouse modelmurine modelnecrocytosisnerve cementneural inflammationneuro-AIDSneuro-HIVneuroAIDSneuroHIVneuroinflammationneuroinflammatorynew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapeuticsnew therapynew therapy approachesnew therapy targetnew treatment approachnew treatment strategynext generation therapeuticsnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy approachnovel therapy targetpathwaypeople infected with HIVpeople infected with human immunodeficiency viruspeople living with HIVpeople with HIVpeople with human immunodeficiency virusperivascular glial cellpersistent HIVpersistent HIV-1persistent human immunodeficiency viruspharmacologicprotein blottingresponsesiRNAsocial rolesubstance abusesubstance misusetargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targettherapy adherencetherapy compliancetoll-like receptor 4transcriptional silencingvalidationsvirus protein
Description preview
Abstract:
Despite the advent of combination antiretroviral therapy (cART), HIV-associated neurocognitive disorders (or
NeuroHIV) remain prevalent, affecting 30-50% of patients and presenting persistent challenges in managing
neurological complications. Glial cell dysregulation, particularly microglia and astrocytes, drives chronic…
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