grant
Molecular Interplay of Endocytic Proteins
Organization FRED HUTCHINSON CANCER CENTERLocation SEATTLE, UNITED STATESPosted 15 Feb 2020Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY2026AffectAgingAmino AcidsAnimalsAssayAutophagosomeBindingBinding ProteinsBioassayBiochemicalBiogenesisBiological AssayBiologyBrainBrain Nervous SystemBypassC elegansC elegans genomeC. elegansC. elegans genomeC.elegansC.elegans genomeCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCaenorhabditis elegansCaenorhabditis elegans genomeCas nuclease technologyCell Communication and SignalingCell SignalingClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyDNA mutationDataDegenerative Neurologic DisordersDown SyndromeElectron MicroscopyElectrophysiologyElectrophysiology (science)EncephalonEndocytosisEpilepsyEpileptic SeizuresEpilepticsEvolutionExhibitsFluorescenceGeneticGenetic ChangeGenetic ScreeningGenetic defectGenetic mutationHaploidHaploidyHealthImpairmentIntracellular Communication and SignalingL-SerineLangdon Down syndromeLeucineLifeLigand Binding ProteinLigand Binding Protein GeneLinkLipidsLocomotionMapsMeasuresMediatingMembraneMiceMice MammalsModelingMolecularMolecular InteractionMongolismMorphologyMurineMusMutateMutationNerve Impulse TransmissionNerve TransmissionNervous System Degenerative DiseasesNervous System DiseasesNervous System DisorderNeural Degenerative DiseasesNeural TransmissionNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologicNeurologic Degenerative ConditionsNeurologic DisordersNeurologicalNeurological DisordersNeuronal TransmissionNeurophysiology / ElectrophysiologyOrigin of LifePARK20PHluorinParalysis AgitansParkinsonParkinson DiseasePhosphatasesPhosphohydrolasesPhosphomonoesterasesPhosphoric Monoester HydrolasesPhysiologicPhysiologicalPhysiologyPlayPoint MutationPrimary ParkinsonismProcessProline-Rich DomainProline-Rich RegionPropertyProtein BindingProteinsRecyclingRegulationResearchRoleSH3 DomainsSRC Homology Region 3 DomainSYNJ1SYNJ1 geneSeizure DisorderSerineShapesSignal TransductionSignal Transduction SystemsSignalingSiteSynapsesSynapticSynaptic TransmissionSynaptic VesiclesTestingTrisomy 21Workage associatedage correlatedage dependentage linkedage relatedage specificalpha helixaminoacidaxon signalingaxon-glial signalingaxonal signalingbiological signal transductionbound proteinchromosome 21 trisomychromosome 21 trisomy syndromecongenital acromicria syndromedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdesigndesigningelectrophysiologicalepilepsiaepileptogenicgenome mutationglia signalingglial signalingin vivoinsightlife spanlifespanmembrane structuremorbus Downmutantnerve signalingneural circuitneural circuitryneural signalingneurocircuitryneurodegenerative illnessneurological diseaseneuronal signalingneurotransmissionnovelpreservationprotein protein interactionpseudohypertrophic progressive muscular dystrophyrecruitresponsescreeningscreeningssocial rolesynapsesynapse functionsynaptic circuitsynaptic circuitrysynaptic functionsynaptojaninsynaptojanin-1synaptojanin1trisomy 21 syndromeα-helix
Description preview
Project summary
Synaptic vesicle endocytosis plays a crucial role in sustaining effective neurotransmission and supporting
neural circuit stability. Disruptions in this process can weaken synaptic signaling, contributing to neurological
disorders such as Parkinson's disease, Down syndrome, and epilepsy. Two proteins that play key roles in
synaptic…
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