grant
Molecular Imaging and Metabolotheranostics of PDAC-Induced Cachexia
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 1 Apr 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2026B7-H1BenignBiodistributionBlood PlasmaBody TissuesBody WeightBody Weight decreasedBrainBrain Nervous SystemBreast Cell GlutaminaseCAT scanCD274CD47CD47 AntigenCD47 GlycoproteinCD47 geneCT X RayCT XrayCT imagingCT scanCachecticCachexiaCancer CachexiaCancer TreatmentCancersCell BodyCellsClinical TrialsComputed TomographyDataDextransDown-RegulationEC 3.5.1.2EncephalonEnvironmentFrequenciesFunctional ImagingGA ProteinGenesGlnGlutamatesGlutaminaseGlutamineHeterograftHeterologous TransplantationHumanImageImmuneImmune mediated therapyImmunesImmunocompetentImmunologically Directed TherapyImmunomodulationImmunotherapyIntegrin-Associated ProteinIntercellular FluidIntermediary MetabolismInterstitial FluidsL glutamine amidohydrolaseL-GlutamateL-GlutamineLiver GlutaminaseMER6MR SpectroscopyMagnetic Resonance SpectroscopyMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant Pancreatic NeoplasmMalignant TumorMalignant neoplasm of pancreasMessenger RNAMetabolicMetabolic PathwayMetabolic ProcessesMetabolismMiceMice MammalsModern ManMolecularMorbidityMurineMusMuscle AtrophyMuscular AtrophyMyeloid-derived suppressor cellsOrganOrgan WeightPD-L1PDA modelPDAC ModelPDAC cancer cellPDAC cellPDL-1PancreasPancreas CancerPancreas Ductal AdenocarcinomaPancreaticPancreatic CancerPancreatic Ductal AdenocarcinomaPathway interactionsPatientsPhysiologic ImagingPlasmaPlasma SerumPopulationProgrammed Cell Death 1 Ligand 1Programmed Death Ligand 1ProteinsQ LevoglutamideQ. LevoglutamideQOLQuality of lifeReticuloendothelial System, Serum, PlasmaRoleSamplingSeveritiesShort interfering RNASmall Interfering RNASolidSpleenSpleen Reticuloendothelial SystemSurface Antigen Identified by Monoclonal Antibody 1D8SyndromeT-CellsT-LymphocyteTNFBRTNFR2TNFR80TNFRSF1BTNFRSF1B geneTherapeuticTissuesTomodensitometryTumor Necrosis Factor Beta ReceptorTumor TissueTumor VolumeTumor-DerivedVisceralWeightWeight LossWeight ReductionX-Ray CAT ScanX-Ray Computed TomographyX-Ray Computerized TomographyXenograftXenograft procedureXenotransplantationXray CAT scanXray Computed TomographyXray computerized tomographyanti-cancer therapybiocompatibilitybiomaterial compatibilitybody weight losscancer associated cachexiacancer induced cachexiacancer therapycancer-associated muscle wastingcancer-directed therapycancer-induced muscle atrophycancer-induced muscle losscancer-induced muscle wastingcancer-related cachexiacatscanchemotherapycomputed axial tomographycomputer tomographycomputerized axial tomographycomputerized tomographydeliver short interfering RNAdeliver siRNAdeliver small interfering RNAdelivery system for siRNAdelivery system for small interfering RNAdelivery vectors for siRNAdesigndesigningdextranexhaustionexperienceglutamatergichigh definitionhigh-resolutionhuman tissueimage guidanceimage guidedimagingimaging capabilitiesimaging mass spectrometryimmune check pointimmune checkpointimmune competentimmune microenvironmentimmune modulationimmune regulationimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmunecheckpointimmuno therapyimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunosuppressive microenvironmentimmunosuppressive myeloid cellsimmunosuppressive tumor microenvironmentimprovedin vivoinhibitormRNAmalignancymass spectrometric imagingmolecular imagingmolecule imagingmortalitymouse modelmurine modelmuscle breakdownmuscle bulkmuscle degradationmuscle deteriorationmuscle formmuscle lossmuscle massmuscle wastingmyeloid suppressor cellsmyeloid-derived suppressive cellsnano particlenano particle deliverynano-sized particlenanoparticlenanoparticle deliverednanoparticle deliverynanosized particleneoplasm/cancernon-contrast CTnoncontrast CTnoncontrast computed tomographypancreatic cancer modelpancreatic cancer patientspancreatic ductal adenocarcinoma cellpancreatic ductal adenocarcinoma modelpancreatic malignancypancreatic tumor modelpathwaypatients with pancreatic cancerpharmacologicphysiological imagingpre-clinicalpre-clinical studypreclinicalpreclinical studyprogrammed cell death ligand 1programmed cell death protein ligand 1protein death-ligand 1responseresponse to therapyresponse to treatmentshort interfering RNA deliverysiRNAsiRNA deliverysmall interfering RNA deliverysocial rolesuppressive myeloid cellstheranosticstherapeutic responsetherapy responsethymus derived lymphocytetranscriptomicstreatment effecttreatment responsetreatment responsivenesstumortumor growthtumor immune microenvironmenttumor necrosis factor receptor superfamily, member 1Btumor-immune system interactionstumor-induced cachexiatumor-induced muscle wastingvectorweightswt-lossxeno-transplantxeno-transplantation
Description preview
Cachexia induced by pancreatic ductal adenocarcinoma (PDAC) results in significant morbidity, mortality, and
poor response to treatment including immune therapy. We intend to apply our molecular and functional imaging
capabilities, and our experience in developing theranostic nanoparticles (NPs) that deliver small interfering RNA
(siRNA), to focus…
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