grant
Molecular determinants of ensemble recruitment by drugs of abuse
Organization VANDERBILT UNIVERSITYLocation Nashville, UNITED STATESPosted 1 Jul 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2026ATAC sequencingATAC-seqATACseqAblationAcetate EsteraseAcetic-ester acetylhydrolaseAcetylaseAcetylationAcetylesteraseAcetyltransferaseAcid EsteraseAcuteAnimalsArchitectureAssay for Transposase-Accessible Chromatin using sequencingBar CodesBehaviorBehavior ControlBehavioral ManipulationBig DataBigDataBrainBrain Nervous SystemBrain regionCUT&RUNCell BodyCell NucleusCellsChromatinCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseCocaineCocaine use disorderComplexD1 receptorDNADNA RecombinationDataDeoxyribonucleic AcidDopamine D1 ReceptorDrug ControlsDrug ExposureDrug TherapyDrug usageDrugsEncephalonEngineering / ArchitectureEnvironmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEsterase-17FluorescenceGene ExpressionGene TranscriptionGenesGenetic MarkersGenetic RecombinationGenetic TranscriptionGoalsHistone H3HistonesImageImmediate-Early GenesL-LysineLabelLinkLysineMaintenanceMediatingMediatorMedicationMiceMice MammalsMolecularMolecular TargetMurineMusNerve CellsNerve UnitNeural CellNeurocyteNeuronsNucleosomesNucleusNucleus AccumbensPatternPharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPhosphorylationPhysiologicPhysiologicalPlayPopulationProcessProtein PhosphorylationProteinsPsychological reinforcementRNA ExpressionRecombinationReinforcementResolutionRewardsRoleSAGASPT/ADA/Gcn5 AcetyltransferaseSalineSaline SolutionSelf AdministeredSelf AdministrationSingle-Nucleus SequencingSortingStimulusSynaptic plasticityTechnologyTestingTimeTranscriptionTransgenesViral VectorWorkabused drugabused drugsaddictionaddictive disorderassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingawakebarcodebehavioral controlbehavioral plasticitybrain controlcocaine exposurecocaine rewardcocaine self-administrationcocaine-exposeddensitydrug abuseddrug interventiondrug of abusedrug treatmentdrug usedrug/agentdrugs abuseddrugs of abuseendomicrosopeepigenetic profilingepigenetic regulationepigeneticallyexperienceexposed to cocaineexposure to cocainefrontiergene biomarkergene expression biomarkergene markergene signature biomarkergenetic biomarkergenome scalegenome-widegenomewidehigh dimensional datahistone modificationimagingloss of functionloss of function mutationmembermicroendoscopemultidimensional datamultidimensional datasetsmutantneuralneuronaloverexpressoverexpressionpermissivenesspharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspreventpreventingrecruitresolutionssNuc-Seqsegregationself-administer cocainesingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqsocial roletransgenetreatment strategy
Description preview
ABSTRACT
While a large amount of work has focused on how stimuli are encoded in the transcriptional and
physiological activity patterns within genetically defined neuronal populations, emerging evidence has clearly
shown that stimuli activate only a small percentage of neurons in any given brain region. Therefore,
understanding how specific…
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