grant
Molecular Determinants of Chromosome Transmission and Cell Cycle Regulation
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025AneuploidAneuploidyAreaAssayBaker's YeastBasic Mechanisms of SUMOylationBasic ResearchBasic ScienceBioassayBiochemicalBiological AssayBreast Cancer cell lineBreast tumor cell lineBrewer's YeastBudding YeastCENP-ACancer PrognosisCancer TreatmentCancersCell BodyCell CycleCell Cycle ControlCell Cycle RegulationCell Division CycleCellsCellular biologyCentromereChaperoneChromatinChromosomal InstabilityChromosomal StabilityChromosome InstabilityChromosome SegregationChromosome StabilitiesChromosomesClinicComplexDNADNA mutationDefectDeoxyribonucleic AcidDiagnosisEndomycetalesGene Copy NumberGene DosageGenesGeneticGenetic ChangeGenetic defectGenetic mutationHeterograftHeterologous TransplantationHistone H3Histone H4HistonesHumanKinasesKinetochoresMDA MB 231MDA-231MDA-MB231MaintenanceMalignant CellMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMediatingMethylationMiceMice MammalsMicro-tubuleMicrotubulesMitotic ChromosomeModern ManMolecularMolecular ChaperonesMolecular ConfigurationMolecular ConformationMolecular StereochemistryMurineMusMutationNuclearNucleic AcidsOncogenesisPathway interactionsPhenotypePhosphoprotein PhosphatasePhosphoprotein Phosphatase-2CPhosphoprotein PhosphohydrolasePhosphorylation SitePhosphotransferase GenePhosphotransferasesPlayPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProcessPrognosisProliferatingProtein CleavageProtein ModificationProtein Phosphatase CProtein Phosphatase GeneProtein Phosphatase-1Protein Phosphatase-2AProtein phosphataseProteinsProteolysisRegulationResearchRoleS cerevisiaeS. cerevisiaeSUMOylationSaccharomyces cerevisiaeSaccharomycetalesShort interfering RNASiteSmall Interfering RNASumoylation PathwayTNBCTranslatingTransmissionTransphosphorylasesUbiquitin-mediated ProteolysisUbiquitin-mediated Proteolysis PathwayXenograftXenograft procedureXenotransplantationYeastsanti-cancer researchanti-cancer therapybeta-TrCPbeta-Transducin Repeat-Containing ProteinsbetaTrCPcancer cellcancer researchcancer therapycancer-directed therapycell biologycentromere autoantigens 17Kcentromere protein 17Kcentromere protein Achromosome divisionclinical relevanceclinically relevantconformationconformationalconformational stateconformationallyconformationsgenome mutationgenome scalegenome-widegenomewidein vivoinsightinterdisciplinary approachmalignancymouse modelmultidisciplinarymultidisciplinary approachmurine modelneoplasm/cancernoveloncohistoneoverexpressoverexpressionpathwaypreventpreventingsiRNAsocial rolestoichiometrysupply chaintargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttooltransmission processtriple-negative breast cancertriple-negative invasive breast carcinomatumorigenesisxeno-transplantxeno-transplantationβ-TrCPβ-Transducin Repeat-Containing ProteinsβTrCP
Description preview
We use multi-organismal (yeast, xenograft mouse and human cells) and multi-disciplinary (genetic, cell biology, biochemical and genome-wide) approaches to study chromosomal stability. We have pioneered studies in these areas and determined that a balanced stoichiometry of kinetochore proteins, topology of centromeric chromatin and…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click