grant
Molecular control of age-related retinal synaptic remodeling
Organization BOSTON CHILDREN'S HOSPITALLocation BOSTON, UNITED STATESPosted 1 Aug 2020Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY2026(hydroxymethylglutaryl-CoA reductase (NADPH)) kinase5'-AMP-activated protein kinaseAMP-activated kinaseAMP-activated protein kinaseAMPK enzymeAccelerationAffectAge related macular degenerationAge-Related MaculopathyAgingAnabolismAnatomic SitesAnatomic structuresAnatomyAssayAtrophic AMDAtrophic age-related macular degenerationAxonAxon TerminalsAxonal TransportAxoplasmic TransportBasal Transcription FactorBasal transcription factor genesBioassayBiogenesisBiological AssayBrainBrain Nervous SystemCell BodyCell Culture TechniquesCellsCircadian DysregulationClinical TrialsD-GlucoseDataDegenerative DisorderDevelopmentDextroseDiminished VisionDistalDry AMDDysfunctionElectron MicroscopyElectroretinographyEncephalonEnergy SupplyFerroprotoporphyrinFunctional disorderGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic TranscriptionGenus HippocampusGlucoseGoalsHMG CoA reductase (NADPH) kinaseHMG CoA reductase kinaseHMG coenzyme A reductase (NADPH) kinaseHealthHemeHumanImpairmentInjuryIntermediary MetabolismKinasesKnowledgeLinkLiverLow VisionMediatingMetabolicMetabolic ControlMetabolic PathwayMetabolic ProcessesMetabolic dysfunctionMetabolic stressMetabolismMiceMice MammalsMicro-tubuleMicrotubulesMitochondriaModern ManMolecularMorphologyMurineMusNerve CellsNerve RegenerationNerve UnitNeural CellNeural TransmissionNeuro-regenerationNeurocyteNeuronal InjuryNeuronsNeuroregenerationNon-exudative age-related macular degenerationNonexudative age-related macular degenerationNuclear ReceptorsObesityOrigin of LifeOxidation-ReductionOxidative StressPartial SightPathologicPathway interactionsPatientsPhosphotransferase GenePhosphotransferasesPhotoreceptor CellPhotoreceptorsPhotosensitive CellPhysiopathologyPresynaptic Nerve EndingsPresynaptic TerminalsProcessProteinsProtohemeRNA ExpressionRedoxReduced VisionRegulationReporterRetinaRetinal DegenerationRetinal DetachmentRodRod PhotoreceptorsRodentRodentiaRodents MammalsRoleSeahorseSightSiteSkeletal MuscleSubnormal VisionSynapsesSynapticSynaptic BoutonsSynaptic TerminalsSynaptic TransmissionTherapeuticTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTransphosphorylasesVisionVisual ReceptorVisual impairmentVoluntary MuscleWorkaccelerated agingaccelerated biological ageaccelerated biological agingadiposityage accelerationage associatedage associated alterationsage associated changesage associated effectsage correlatedage correlated alterationsage correlated changesage dependentage dependent alterationsage dependent changesage dependent macular degenerationage effectage induced alterationsage induced changesage induced macular degenerationage linkedage relatedage related alterationsage related changesage related effectsage related macular diseaseage related macular dystrophyage specificage specific alterationsage specific changesaging associated alterationsaging associated changesaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging effectaging induced alterationsaging induced changesaging related alterationsaging related changesaging specific alterationsaging specific changesalterations with agebiosynthesiscell culturecell cultureschanges with agecircadian abnormalitycircadian disruptioncircadian disturbancecircadian dysfunctioncircadian impairmentcorpulencedegenerative conditiondegenerative diseasedegenerative retina diseasesdesigndesigningdevelopmentaldry age-related macular degenerationelectroretinogramfat metabolismferrohemefluorescence imagingfluorescent imaginghepatic body systemhepatic organ systemhydroxymethylglutaryl-CoA-reductase kinaseimpact of ageimprovedinfluence of ageinjurieslipid metabolismmitochondrialmitochondrial metabolismnervous system regenerationneural regenerationneuron injuryneuronalneuroregenerativenew approachesnovelnovel approachesnovel strategiesnovel strategyoverexpressoverexpressionoxidation reduction reactionpathophysiologypathwaypharmacologicpresynapticpublic health relevancerecruitregenerated nerverepairrepairedretina degenerationretina detachmentretinal degenerativeretinal degenerative diseasesretinal neuronretinal rodsrod cellsenile macular diseasesensorsocial rolesynapsesynapse functionsynaptic functiontraffickingtranscription factortranscriptomicsupstream kinasevision impairmentvisual dysfunctionvisual functionvisually impaired
Description preview
Project Summary
Retinal synaptic remodeling affects visual function and occurs in aging and in age-related macular degeneration
(AMD) as well as in retinal injury and detachment. Strengthening retinal neuronal synapse to maintain their
normal interaction is important to protect visual function in AMD. The high metabolic demand of retinal neurons,…
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