grant
Molecular characterization and modeling efficient antibody effector function
NIHUS FederalResearch GrantFY2026Ab-dependent cellular cytotoxicityAccelerationActinsAffectAffinityAntibodiesAntibody AffinityAntibody ResponseAntibody TherapyAntigen TargetingAntigen-Antibody ComplexAntigenic DeterminantsAntigensAvidityB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBindingBinding DeterminantsBiologicalBiological FunctionBiological ProcessBiologyBlood monocyteCell BodyCell Communication and SignalingCell DegranulationCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessCellular biologyClinicalComplexCytotoxic cellDataDevelopmentEffector CellEncapsulatedEndowmentEpitopesEvaluationEventGenerationsIgG ReceptorsImmuneImmune ComplexImmune responseImmune systemImmunesImmunoglobulin G ReceptorImmunologistImmunotherapeutic agentIntracellular Communication and SignalingIntrinsic factorK lymphocyteLinkMapsMarrow monocyteMath ModelsMediatingMembrane FusionMicro-tubuleMicrotubulesModelingMolecularMolecular InteractionMyeloid CellsNK Cell ActivationNK CellsNatural Killer Cell ActivationNatural Killer CellsOutcomeParticle SizePathogenicityPathologyPhagocytesPhagocytic CellPhagocytosisPhenotypePlayProbabilityProcessPropertyReceptor SignalingRegimenRoleSeriesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStructureSubcellular ProcessTestingTherapeutic antibodiesTranslatingVaccine DesignVaccinesVariantVariationWorkamebocyteantibody based therapiesantibody dependent cell mediated cytotoxicityantibody dependent cytotoxicityantibody engineeringantibody immunotherapyantibody mediated cellular cytotoxicityantibody treatmentantibody-based therapeuticsantibody-based treatmentantibody-dependent cell cytotoxicityantibody-dependent cellular cytotoxicityantibody-mediated cytotoxicityantigen antibody affinityarmbiologicbiological signal transductioncell behaviorcell biologycell killingcell typecellular behaviorclinical developmentdensitydesigndesigningdevelopmentalextracellularflexibilityflexiblegamma Fc Receptorshost responseimmune drugsimmune system responseimmune-based therapeuticsimmunogenimmunologic therapeuticsimmunoresponseimmunotherapeuticsimmunotherapy agentimprovedin vivoinsightmathematic modelmathematical modelmathematical modelingmonocytereceptor expressionresponsesocial rolespatial and temporalspatial temporalspatiotemporalsuccesstraffickingvaccine efficacy
Description preview
ABSTRACT
Antibody effector functions represent a nexus linking innate and adaptive arms of the immune system and also
have direct clinical implications for antibody therapeutics and antibody-mediated pathologies. However, the
potency of Ab-dependent effector responses depends on numerous antigen, antibody and effector cell
properties. Variable…
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