grant
Molecular basis for CRISPR-associated transposons and RNA-guided transcriptional regulation
Organization PURDUE UNIVERSITYLocation WEST LAFAYETTE, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY2025ATP HydrolysisAssayAutomobile DrivingBasic ResearchBasic ScienceBioassayBiochemicalBiologic ModelsBiological AssayBiological ModelsBiotechBiotechnologyCRISPRCRISPR transposonCRISPR-Cas transposonsCRISPR-associated transposonsCRISPR/Cas systemClustered Regularly Interspaced Short Palindromic RepeatsComplexCryo-electron MicroscopyCryoelectron MicroscopyDNADedicationsDeoxyribonucleic AcidDevelopmentElectron CryomicroscopyEnzyme ActivationGene Action RegulationGene Expression RegulationGene RegulationGene Regulation ProcessGenomeGoalsGuide RNAMedicineModel SystemMolecularResearchRoleSpecificitySystemTherapeutic ResearchTranscriptional ControlTranscriptional RegulationWorkbiological systemscryo-EMcryoEMcryogenic electron microscopydevelopmentaldrivingflexibilityflexiblegRNAgenome editinggenomic editinginsightnext generationparticlerational designsocial roletooltransposon-associated CRISPR-Cas
Description preview
Project Summary
Our research is dedicated to elucidating the molecular mechanisms of RNA-guided biological
systems, with a focus on CRISPR-associated transposons (CASTs) and emerging RNA-guided
gene regulation functions. Leveraging our expertise in single-particle cryo-electron microscopy
and a broad array of biochemical and functional assays, we…
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