grant
Molecular architecture of the human knee joint and pelvis at single cell resolution
Organization HARVARD UNIVERSITYLocation CAMBRIDGE, UNITED STATESPosted 1 Apr 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DATAC sequencingATAC-seqATACseqAgingAnatomic SitesAnatomic structuresAnatomyArchitectureArticular CapsuleArticular ligamentsAssayAssay for Transposase-Accessible Chromatin using sequencingBasal Transcription FactorBasal transcription factor genesBehaviorBioassayBiologicalBiological AssayBiologyBody TissuesBone FormationBone structureCUT&RUNCapsula ArticularisCartilageCartilaginous TissueCell BodyCell DifferentiationCell Differentiation processCell FunctionCell Growth in NumberCell IsolationCell MultiplicationCell PhysiologyCell ProcessCell ProliferationCell SegregationCell SeparationCell Separation TechnologyCell-Extracellular MatrixCellsCellular FunctionCellular PhysiologyCellular ProcessCellular ProliferationCellular biologyChondrocytesChromatinCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseCommunitiesComplexConnective TissueCoxaData SetDevelopmentDevelopmental ProcessDifferential Gene ExpressionDiseaseDisorderDistalECMElementsEngineering / ArchitectureEnsureEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpiphyseal PlateEpiphysial cartilageEventExpression SignatureExtracellular MatrixExtremitiesFemurFibroblastsGene ExpressionGene Expression ProfileGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenesGeneticGenetic ProcessesGenetic TranscriptionGenomic SegmentGenomicsGrantGrowthGrowth PlateHipHip JointHip region structureHistologicHistologicallyHumanImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodIn Situ HybridizationIn VitroIndividualInvestigationInvestigatorsJoint CapsuleJointsKneeKnee jointKnowledgeLigamentsLimb structureLimbsLinkLoad BearingLocationLocomotionMediatingMedicalMembrana Synovialis Capsulae ArticularisMeniscusMeniscus structure of jointMethodsModern ManMolecularMolecular FingerprintingMolecular ProfilingMorphologyMultiomic DataMusculoskeletalNon-TrunkNucleic Acid Regulator RegionsNucleic Acid Regulatory SequencesOrthopedicOrthopedic Surgical ProfessionOrthopedicsOsteogenesisPatternPelvicPelvic RegionPelvisPharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePhenotypePopulationProcessPropertyProtocolProtocols documentationRNA ExpressionRNA SeqRNA sequencingRNAseqRegenerative MedicineRegulatory ElementRegulatory RegionsReporterResearchResearch PersonnelResearch ResourcesResearch SpecimenResearchersResolutionResourcesRoleSamplingShapesSkeletonSpecimenStructureSubcellular ProcessSynovial CapsuleSynovial MembraneSynoviumTechnologyTherapeuticTissue GrowthTissue-Specific Differential Gene ExpressionTissue-Specific Gene ExpressionTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesWeight BearingWeight-Bearing stateacetabulumassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbiologicbone tissue formationcartilage cellcell biologycell sortingcellular differentiationdevelopmentaldevelopmental diseasedevelopmental disorderepigeneticallyfemur headfunctional genomicsgene expression patterngene expression signaturegenetic regulatory elementgenome segmentgenomic regioniliumin situ Hybridization Geneticsin situ Hybridization Staining Methodin uteroin vivoinnovateinnovationinnovativeinsightischiumjoint ligamentmolecular profilemolecular signaturemultiomicsmultiple omic datamultiple omicsnovelontogenypanomicspharmaceuticalpopulation basedprogramsregeneration based therapyregeneration therapyregenerative therapeuticsregenerative therapyresolutionsscATAC sequencingscATAC-seqscRNA sequencingscRNA-seqsingle cell ATAC-seqsingle cell ATAC-sequencingsingle cell Assay for Transposase Accessible Chromatin sequencingsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell sequencing assay for transposase accessible chromatinsingle cell transcriptomic profilingsingle-cell Assay for Transposase-Accessible Chromatin with sequencingsingle-cell RNA sequencingsingle-cell assay for transposase-accessible chromatin using sequencingsingle-cell assay for transposase-accessible chromatin-seqskeletalskeletal diseaseskeletal disorderskeletal maturationskeletal structureskeletonssocial rolesoft tissuespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial relationshipspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsthree dimensionaltibiatooltranscription factortranscriptional profiletranscriptional signaturetranscriptome sequencingtranscriptomic sequencingtranscriptomics
Description preview
Project Summary/Abstract
At the cornerstone of human bipedal locomotion are the pelvis and knee, two hind limb skeletal structures for
which we know little about their respective development in humans. Indeed, these structures have complex
3-D morphologies whose initial patterns arise during the chondrogenic anlagen stage, when coordinated…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click