grant
Molecular and structural mechanisms of metazoan origin licensing
NIHUS FederalResearch GrantFY2025BindingBiochemicalBiologic ModelsBiological ModelsBiophysicsBudding YeastCancersCell Growth in NumberCell MultiplicationCell ProliferationCellular ProliferationChromatinChromosomal AmplificationChromosomal DuplicationDNADNA BindingDNA Binding InteractionDNA HelicasesDNA ReplicationDNA Replication InitiationDNA SynthesisDNA Unwinding ProteinsDNA biosynthesisDNA boundDNA replication originDNA unwinding enzymeDefectDeoxyribonucleic AcidDepositDepositionDevelopmentDiseaseDisorderEndomycetalesEukaryotaEukaryoteHumanIn VitroKnowledgeLaboratoriesLicensingLinkMalignant NeoplasmsMalignant TumorModalityModel SystemModern ManMolecularMolecular InteractionMotorORC proteinOrganismPathway interactionsProcessProteinsReplication InitiationReplication LicensingReplication OriginResearchResolutionSaccharomycetalesStructureSyndromeSystemWorkbiophysical foundationbiophysical principlesbiophysical sciencescofactordevelopmentalgenetic informationgenome integritygenomic integrityhelicasehuman diseaseliving systemmalignancyneoplasm/cancernew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachori Regionorigin recognition complexpathwayprogramsreconstitutereconstitutionrecruitresolutionsstructural biology
Description preview
Abstract
The survival of living organisms depends on the timely and accurate duplication of chromosomal DNA. Defects
in DNA replication jeopardize genome integrity and organismal viability and are linked to numerous diseases
ranging from developmental syndromes to cancer. Research in my laboratory is broadly focused on elucidating
the mechanisms…
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