grant
Molecular and Spatial Factors Defining Tumor-specific CD8 T Cell States in Cold Tumors
Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 16 Jul 2025Deadline 15 Jul 2029
NIHUS FederalResearch GrantFY2025(TNF)-αAbscissionAntigensAutoimmuneAutoimmune DiseasesBasal Transcription FactorBasal transcription factor genesBeta Cell NeoplasmBeta Cell Neoplasm of the PancreasBeta Cell Tumor of the PancreasBody TissuesBreastBreast CancerBrittle Diabetes MellitusCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCachectinCancer GenesCancer-Promoting GeneCarcinomaCas nuclease technologyCategoriesCell BodyCell CommunicationCell FunctionCell InteractionCell PhysiologyCell ProcessCell-to-Cell InteractionCellsCellular FunctionCellular PhysiologyCellular ProcessClassificationClinicalClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCollaborationsCommon Rat StrainsEctopic ExpressionEpithelial cancerExcisionExhibitsExtirpationFamilyGeneral Transcription Factor GeneGeneral Transcription FactorsGenesHumanHumulin RIDDMIFN-GammaIFN-gIFN-γIFNGIFNγImmuneImmune InterferonImmune mediated therapyImmunesImmunizationImmunofluorescenceImmunofluorescence ImmunologicImmunologically Directed TherapyImmunotherapeutic agentImmunotherapyImpairmentInfiltrationInsulinInsulin-Dependent Diabetes MellitusInsulin-Producing Neoplasm of the Islet CellsInsulin-Producing Tumor of the Islet CellsInsulomaInterferon GammaInterferon Type IIInterventionIsland Cell TumorIslet Cell NeoplasmIslet Cell TumorJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusKnowledgeLEF Transcription FactorLYT3Large T AntigenLymphoid Enhancer FactorMSKCCMacrophage-Derived TNFMalignant Breast NeoplasmMalignant CellMalignant Epithelial NeoplasmsMalignant Epithelial TumorsMalignant Pancreatic NeoplasmMalignant neoplasm of pancreasMediatingMemorial Sloan-Kettering Cancer CenterMiceMice MammalsMicroscopyModelingModern ManMolecularMolecular AnalysisMonocyte-Derived TNFMucinousMurineMusNovolin ROncogenesOncogenesisOncogenicPD 1PD-1PD1PanNetsPancreasPancreas CancerPancreas Ductal AdenocarcinomaPancreas NeoplasmsPancreas TumorPancreaticPancreatic Beta Cell Insulin Producing NeoplasmPancreatic Beta Cell Insulin Producing TumorPancreatic Beta Cell TumorPancreatic CancerPancreatic Ductal AdenocarcinomaPancreatic Endocrine NeoplasmPancreatic Endocrine TumorPancreatic Neuroendocrine TumorPancreatic TumorPapillaryPathway interactionsPatientsPhenotypePolyomavirus macacaePolyomavirus maccacae 1PositionPositioning AttributePre-Clinical ModelPreclinical ModelsPreclinical dataPrognostic MarkerRatRats MammalsRattusReceptor ProteinRegular InsulinRemovalResearchResistanceRoleSV 40SV 40 VirusSV40SV40 VirusSamplingSimian Vacuolating Virus 40Simian virus 40Solid NeoplasmSolid TumorStem Cell likeSubcellular ProcessSudden-Onset Diabetes MellitusSurgical RemovalSystematicsT Cell FactorT cell based immune therapyT cell based therapeuticsT cell based therapyT cell differentiationT cell directed therapiesT cell immune therapyT cell immunotherapyT cell infiltrationT cell targeted therapeuticsT cell therapyT cell treatmentT cell-based immunotherapyT cell-based treatmentT cellular immunotherapyT cellular therapyT lymphocyte based immunotherapyT lymphocyte based therapyT lymphocyte therapeuticT lymphocyte treatmentT-CellsT-LymphocyteT-cell inflamedT-cell therapeuticsT-cell transfer therapyT1 DMT1 diabetesT1DT1DMT8 CellsT8 LymphocytesTCF Transcription FactorTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTherapeuticTimeTissuesTranscription Factor Proto-OncogeneTranscription factor genesTransforming GenesTranslatingTumor AntigensTumor Necrosis FactorTumor Necrosis Factor-alphaTumor-Associated AntigenType 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusVaccinationVacuolating AgentWorkadoptive T cell transferadoptive T lymphocyte transferadoptive T-cell therapyautoimmune conditionautoimmune disorderautoimmunity diseasebeta-Cell Adenomabeta-Cell Tumorcancer antigenscancer cellcancer infiltrating T cellscancer initiationcancer microenvironmentcancer progressioncancer typecheck point blockadecheckpoint blockadeclinical relevanceclinically relevantcytokinedesigndesigningdraining lymph nodeepithelial carcinomaexhausthuman cancer mouse modelimmune check point blockadeimmune checkpoint blockadeimmune drugsimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapeuticsimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenimmunogenicimmunologic therapeuticsimmunotherapeuticsimmunotherapy agentinsightinsulin dependent diabetesinsulin dependent type 1insulinomajuvenile diabetesjuvenile diabetes mellitusketosis prone diabeteslFN-Gammaloss of functionmalignant breast tumormouse modelmurine modelneoplasm progressionneoplastic progressionpancreatic NETpancreatic islet neoplasmpancreatic malignancypancreatic neoplasiapancreatic neoplasmpathwaypatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespreclinical findingspreclinical informationpreventpreventingprogenitorprogenitor capacityprogenitor cell likeprogenitor-likeprognostic biomarkerprognostic indicatorprogrammed cell death 1programmed cell death protein 1programmed death 1programspromoterpromotorreceptorregional lymph noderesectionresistance mechanismresistantresistant mechanismresponseself-renewself-renewalsle2social rolestem cell characteristicsstem-likestemnesssystemic lupus erythematosus susceptibility 2therapeutic T-cell platformthymus derived lymphocytetranscription factortumortumor infiltrating T cellstumor microenvironmenttumor progressiontumor-specific antigentumorigenesistype I diabetestype one diabetesvacuolating virus
Description preview
PROJECT SUMMARY
Solid tumors can be classified into two broad categories, T cell inflamed (hot) and non-T cell inflamed (cold)
tumors. While hot tumors are characterized by a tumor microenvironment enriched in T cells, cold tumors of the
immune dessert phenotype, (e.g. pancreatic and breast) lack T cell infiltration. Human cold tumors exhibit…
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