grant
Molecular and Cellular Profiling of the Habenulointerpeduncular Circuit in Opioid Tolerance and Withdrawal
Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 15 Sept 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY202521+ years oldAbstinenceActiqAcuteAdultAdult HumanAffectAffectiveAnalgesic AgentsAnalgesic DrugsAnalgesic PreparationAnalgesicsAnodynesAntinociceptive AgentsAntinociceptive DrugsAssayAxon TerminalsBNOSBasal Transcription FactorBasal transcription factor genesBehaviorBehavioralBindingBioassayBiological AssayCalciumChronicConsumptionDataDevelopmentDevelopment and ResearchDihydrohydroxycodeinoneDoseDrug ExposureDrugsDuragesicExposure toExpression SignatureFeedbackFemaleFentanestFentanylFentylFiberFoundationsFutureGene ExpressionGene Expression ProfileGeneral Transcription Factor GeneGeneral Transcription FactorsGoalsHabenulaHomeIndividualIntakeIntoxicationMedialMediatingMediatorMedicalMedicationMiceMice MammalsMolecularMolecular InteractionMolecular TargetMoodsMurineMusNC-NOSNGS MethodNGS systemNNOSNOS 1 proteinNOS type INOS1 proteinNerve CellsNerve UnitNeural CellNeural Constitutive Nitric Oxide SynthaseNeurocyteNeuronsNicotineNicotine WithdrawalNitric Oxide Synthase Type IOpiate AddictionOpiate DependenceOpiatesOpioidOralOverdoseOxycodeinonOxycodoneOxycodone SROxycontinPathway interactionsPatientsPersonsPharmaceutical PreparationsPhentanylPhotometryPlayPre-Clinical ModelPreclinical ModelsPresynaptic Nerve EndingsPresynaptic TerminalsPreventionPsychiatryPublishingR & DR&DRegulationRewardsRibosomesRoleRoxicodoneSolidSynaptic BoutonsSynaptic TerminalsTestingTherapeuticTimeTranscription Factor Proto-OncogeneTranscription factor genesUnited StatesUpregulationViralWithdrawalWorkZincZn elementaddictionaddictive disorderadulthoodbehavioral tolerancebrain nitric oxide synthasecholinergicchronic pain patientclinical practicedevelop therapydevelopmentaldrinking waterdrug/agenteffective therapyeffective treatmentfeasibility testinggene expression patterngene expression signaturehomesinsightinterpeduncular nucleusintervention developmentknock-downknockdownlicit opioidmalemu opioid receptorsmulti-drug tolerancemultidrug abusemultidrug tolerancemultiple drug abusemultiple drug tolerancenNOS enzymeneuralneuronalneuronal NOSneuronal form of nitric oxide synthaseneuronal nitric oxide synthasenew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext gen sequencingnext generation sequencingnext generation therapeuticsnextgen sequencingnitric oxide synthase 1novel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyopiate crisisopiate medicationopiate toleranceopiate use disorderopiate withdrawalopioid addictionopioid crisisopioid dependenceopioid dependentopioid detoxopioid detoxificationopioid epidemicopioid habituationopioid medicationopioid toleranceopioid use disorderopioid withdrawaloverdose deathoverdose fatalitiespain killerpain medicationpain relieverpainkillerpathwaypatient with chronic painpolydrug abusepostsynapticprescribed opiateprescribed opioidprescription opiateprescription opioidpresynapticpreventpreventingresearch and developmentresponsereward circuitrysocial rolesuicidal risksuicide risksynthetic opiatesynthetic opioidtherapeutic agent developmenttherapeutic developmenttherapeutic targettherapy developmenttolerance to opiatestolerant to multiple drugstranscription factortranscriptional profiletranscriptional signaturetreatment developmentμ opioid receptorsμ-ORμOR♀♂
Description preview
ABSTRACT
The present crisis of opioid addiction in the United States highlights how an initial exposure to opioids, often
oxycodone, as a medical patient can lead to escalation of use, misuse and eventually addiction. Chronic
exposure to oxycodone produces tolerance to many of its effects, and it is this development of tolerance that
leads to…
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