grant
Molecular and Cellular Mechanisms of Cerebellar Dysfunction in Neurodevelopmental disorders
Organization BAYLOR COLLEGE OF MEDICINELocation HOUSTON, UNITED STATESPosted 15 Jul 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025AD/HDADHDASDAbnormal coordinationAffectAllelesAllelic LossAllelomorphsAnxietyAtaxiaAtaxyAttention deficit hyperactivity disorderAutismAutistic DisorderB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBasal Transcription FactorBasal transcription factor genesBehaviorBehavioralBiological MarkersBrainBrain Nervous SystemBrain regionCUT&RUNCausalityCell BodyCell Communication and SignalingCell SignalingCellsCerebellar DiseasesCerebellar DisordersCerebellar DysfunctionCerebellar SyndromesCerebellar vermis structureCerebellumCerebellum DiseasesCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseCo-ordination disorderCognitionCognitiveCommunicationComplexConnector NeuronCoordination DisorderCoordination ImpairmentDecreased Muscle ToneDefectDevelopmentDiagnosticDifferential Gene ExpressionDiseaseDisorderDissectionDrosophilaDrosophila genusDyscoordinationDysfunctionDyssynergiaE2A Immunoglobulin Enhancer Binding Factor E12E2A Immunoglobulin Enhancer Binding Factor E47Early Infantile AutismElectrophysiologyElectrophysiology (science)EmbryoEmbryonicEncephalonEpilepsyEpileptic SeizuresEpilepticsEtiologyFibroblastsFunctional disorderGene DeletionGeneHomologGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenotypeGoalsHedgehog (Hh) signal transduction pathwayHomologHomologous GeneHomologueHumanHypomyotoniaHypotoniaImmunoglobulin Transcription Factor 1ImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImpairmentIncoordinationIndividualInfantile AutismIntellectual disabilityIntellectual functioning disabilityIntellectual limitationIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronIntracellular Communication and SignalingKanner's SyndromeKappa-E2-Binding FactorLack of CoordinationLanguageLesionLoss of HeterozygosityMediatorMendelian diseaseMendelian disorderMendelian genetic disorderMiceMice MammalsModern ManMolecularMorbidityMorbidity - disease rateMotorMovementMurineMusMuscle HypotonyMuscle Tone PoorMuscle hypotoniaMuscular HypotoniaNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeuranatomiesNeuranatomyNeuroanatomiesNeuroanatomyNeurocyteNeurodevelopmental DisorderNeurological Development DisorderNeuronal DifferentiationNeuronal DysfunctionNeuronal TransmissionNeuronsNeurophysiology / ElectrophysiologyNeurosciencesPathogenesisPathway interactionsPhenotypePhysiopathologyPredominantly Hyperactive-Impulsive Type Attention-Deficit DisorderPredominantly Hyperactive-Impulsive Type Hyperactivity DisorderProcessProliferatingPurkinje CellsPurkinje's CorpusclesRNA SeqRNA sequencingRNAseqRegulationReportingResearchRoleSHHSHH geneSeizure DisorderSensorySeverity of illnessSignal TransductionSignal Transduction SystemsSignalingSkinSliceSocial BehaviorSonic HedgehogSpecific qualifier valueSpecifiedSyndromeTimeTissue-Specific Differential Gene ExpressionTissue-Specific Gene ExpressionTranscription Factor 3Transcription Factor E2-AlphaTranscription Factor Proto-OncogeneTranscription factor genesVariantVariationWild Type MouseZinc Finger DomainZinc Finger MotifsZinc Fingersautism spectral disorderautism spectrum disorderautistic spectrum disorderaxon signalingaxon-glial signalingaxonal signalingbehavior studybehavioral studybio-markersbiologic markerbiological signal transductionbiomarkerbody movementbrain MR imagingbrain MRIbrain magnetic resonance imagingcandidate identificationcausationcell typecerebellar Purkinje cellcerebral MR imagingcerebral MRIcerebral magnetic resonance imagingco-morbidco-morbiditycohortcomorbiditydevelopmentaldifferential expressiondifferentially expresseddisease causationdisease severityelectrophysiologicalepilepsiaepileptogenicexcitatory neuronexecutive controlexecutive functionfruit flygene deletion mutationgene regulatory networkglia signalingglial signalinggranule cellhedgehog signalinghedgehog signaling pathwayhh signaling pathwayhuman modelin vivoinformation processinginhibitory neuroninnovateinnovationinnovativeinsightintellectual and developmental disabilitylimited intellectual functioningloss of functionmalformationmodel of humanmonogenic diseasemonogenic disordermouse modelmulti-modalitymultimodalitymurine modelnerve signalingneural dysfunctionneural signalingneurobehavioralneurodevelopmental diseaseneuron developmentneuronalneuronal developmentneuronal signalingneuropsychiatricneuropsychiatryneurotransmissionpathophysiologypathwaypostnatalrecruitscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsingle-gene diseasesingle-gene disordersmoothened signaling pathwaysocial rolesociobehaviorsociobehavioraltranscription factortranscriptional differencestranscriptome sequencingtranscriptomic sequencingtranscriptomicsvermiswildtype mouse
Description preview
PROJECT SUMMARY
Neurodevelopmental disorders (NDDs) encompass a broad constellation of highly prevalent and etiologically
heterogeneous disorders that share several key diagnostic features. These include motor incoordination,
abnormal sensory processing, intellectual and developmental disabilities, epilepsy, and neuropsychiatric co-
morbidities…
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