grant
Molecular and cellular mechanisms for bidirectional control of pain in the brain
Organization NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTHLocation UNITED STATES
NIHUS FederalResearch GrantFY2025Absence of pain sensationAbsence of sensibility to painAcute PainAcutely painfulAddressAffectiveAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnatomic SitesAnatomic structuresAnatomyAutomobile DrivingBehaviorBehavioralBehavioral ModelBrainBrain Nervous SystemBrain regionCGRP ReceptorsCalcitonin-Gene Related Peptide ReceptorCell BodyCell Communication and SignalingCell SignalingCellsColitisCollaborationsComputer ModelsComputerized ModelsDifferences between sexesDiffers between sexesDimensionsDisease ProgressionElectrophysiologyElectrophysiology (science)EncephalonFeels no painFore-BrainForebrainGoalsHypersensitivityImageInjuryIntestinalIntestinesIntracellular Communication and SignalingLinkMaintenanceMiceMice MammalsModelingMolecularMolecular GeneticsMorphologyMurineMusNIMHNational Institute of Mental HealthNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurophysiology / ElectrophysiologyNo sensitivity to painNociceptionPainPain ControlPain TherapyPain managementPainfulPathologyPathway interactionsPopulationPopulation DecreasesPositionPositioning AttributeProsencephalonReportingResearchRodentRodentiaRodents MammalsSex DifferencesSexual differencesSignal TransductionSignal Transduction SystemsSignalingSiteSolidStimulusStressStructureSubthalamic structureSubthalamusSynapsesSynapticSystemTexasVisceralWorkacute to chronic pain transitionaffective disturbanceamygdaloid nuclear complexanalgesiabehavior responsebehavioral responsebiological adaptation to stressbiological sex as a modifierbiological signal transductionbowelcell typechronic neuropathic painchronic painchronic pain patientchronic pain transitionco-morbidco-morbiditycomorbiditycomputational modelingcomputational modelscomputer based modelscomputerized modelingcritical injurydevastating injurydisturbance in affectdrivingelectrophysiologicalexpectationexperienceexperimentexperimental researchexperimental studyexperimentsimagingin vivoinjuriesmood alterationmood and affect disturbancemood disturbancemood dysfunctionnerve injuryneural injuryneurochemicalneurochemistryneuronalnociceptivepain chronificationpain interventionpain processingpain treatmentparabrachial nucleuspathwaypatient with chronic painprogramsreaction; crisisresponsesevere injurysex as a biological factorsex as a biological measuresex as a biological risk factorsex as a biological variablesex as a biological variancesex as a biologically significant variablesex as a fundamental variablesex based differencessex dimorphismsex-dependent differencessex-related differencessex-specific differencessexual dimorphismsexually dimorphicsimulationsomatosensorystress responsestress; reactionsynapsetransition to chronic painventral thalamuszona incerta
Description preview
In previous years, we showed that the central amygdala (CeA) functions as a pain rheostat system that can amplify or suppress pain. We further showed that the directionality of pain modulation is dependent on the activity of two subsets of genetically distinct CeA neurons, with activity of one population increasing pain responses and activity of…
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