grant
Molecular and Cellular Dynamics in Mammalian Signal Transduction
Organization UNIVERSITY OF COLORADOLocation Boulder, UNITED STATESPosted 1 Apr 2020Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY2025ATP-protein phosphotransferaseAddressAffectAllosteric RegulationCancersCell BodyCell Communication and SignalingCell SignalingCellsDiseaseDisorderERK 2ERK2ERT1Enzyme GeneEnzymesEventExtracellular Signal-Regulated Kinase 2HumanIntracellular Communication and SignalingKinase Family GeneKnowledgeLaboratoriesMAP Kinase 1MAP Kinase 2MAP kinaseMAPK1MAPK1 Mitogen-Activated Protein KinaseMAPK1 geneMAPK2MAPK2 Mitogen-Activated Protein KinaseMalignant NeoplasmsMalignant TumorMitogen Activated Protein Kinase 1Mitogen-Activated Protein Kinase 2Mitogen-Activated Protein KinasesModern ManMolecularMotionP41MAPKP42MAPKPRKM1PRKM2ProcessProtein KinaseProteinsPublic HealthRegulationResearchSignal TransductionSignal Transduction SystemsSignalingWorkbiological signal transductionglycogen synthase a kinasehuman diseasehydroxyalkyl protein kinaseinhibitormalignancyneoplasm/cancernew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyp42 MAP Kinasep42 MAPKphosphorylase b kinase kinaseresponse
Description preview
PROJECT SUMMARY
This MIRA proposal addresses two important avenues of discovery made by our laboratory. In
Project 1, we will examine a novel mechanism for allosteric regulation of the MAP kinase,
ERK2. This project advances the protein kinase field, by investigating in-depth how protein
motions underlie the activation of ERK and how this affects…
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